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Effect of Anesthetic Choice (Sevoflurane Versus Desflurane) on Speed and Sustained Nature of Airway Reflex Recovery in the Context of Antagonized Neuromuscular Block


Phase 4
18 Years
65 Years
Open (Enrolling)
Both
Airway Reflexes, Protective, Recovery After Neuromuscular Block, Anesthetic Recovery

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Trial Information

Effect of Anesthetic Choice (Sevoflurane Versus Desflurane) on Speed and Sustained Nature of Airway Reflex Recovery in the Context of Antagonized Neuromuscular Block


Inclusion Criteria:



- ASA 1-2 patients

- Age 18-65 years

- body mass index (BMI) ≤ 35kg/m2

- Planned surgery requiring general anesthesia lasting approximately 1.5-3.0 hours

- Surgery requires or benefits from skeletal muscle relaxation

- All must pass the baseline 20 mL water swallowing test as previously described.

Exclusion Criteria:

- Pre-existing neuromuscular or central nervous system disorder

- Known condition interfering with gastric emptying

- Planned surgical procedure on the head or neck

- Known liver disease

- Serum creatinine > 1.5 mg/dL

- Concurrent use of neuroleptic medications

- Contraindication or previous adverse response to any of the study drugs

- Active asthma or reactive airways disease

- Surgery where upright position or brief cough would be contraindicated

- Inability to provide informed consent

Type of Study:

Interventional

Study Design:

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Outcome Measure:

Recovery of ability to swallow after neostigmine/glycopyrrolate antagonism of rocuronium paralysis.

Outcome Time Frame:

At 5 minutes after response to command.

Safety Issue:

Yes

Authority:

United States: Institutional Review Board

Study ID:

H10722-35629-01

NCT ID:

NCT01199237

Start Date:

August 2010

Completion Date:

August 2013

Related Keywords:

  • Airway Reflexes, Protective
  • Recovery After Neuromuscular Block
  • Anesthetic Recovery
  • Reflex, Pharyngeal
  • Anesthetics, Inhalation

Name

Location

UCSF Moffitt-Long HospitalSan Francisco, California  94143
UCSF Helen Diller Cancer CenterSan Francisco, California  94115