Study of Factors Predicting Tumor Recurrence After Liver Transplantation for Hepatocellular Carcinoma
18 Years
70 Years
Both
Hepatocellular Carcinoma, Liver Cirrhosis, Evidence of Liver Transplantation
Trial Information
Study of Factors Predicting Tumor Recurrence After Liver Transplantation for Hepatocellular Carcinoma
In this study, the investigators studied the predictive value of imaging techniques such as
CT, MRI, PET scan, of serological markers and molecular markers assessed before liver
transplantation at listing.
The investigators also evaluated the predictive value of tumor growing during the waiting
time (imaging and serological).
Finally, the investigators compared pre-LT data and explanted liver analysis to evaluate
accuracy of liver biopsy and of imaging.
Inclusion Criteria:
- Liver cirrhosis
- Hepatocellular carcinoma diagnosed by AASLD criteria or liver biopsy
- Listing for Liver transplantation for HCC fulfilling or not Milan criteria
- No extra-hepatic spread
- No vascular involvement
Exclusion Criteria:
- Salvage transplantation
- Transplantation contra-indication
- Evaluation for Liver transplantation older than 1 month
- Incidental HCC
Type of Study:
Observational
Study Design:
Observational Model: Cohort, Time Perspective: Prospective
Outcome Measure:
Predictive factors of HCC recurrence
Outcome Time Frame:
at 1 year after Liver transplantation for HCC
Safety Issue:
No
Principal Investigator
Thomas Decaens, MD, PhD
Investigator Role:
Principal Investigator
Investigator Affiliation:
Assistance Publique - Hôpitaux de Paris
Authority:
France: Ministry of Health
Study ID:
AOM07237
NCT ID:
NCT01198704
Start Date:
January 2009
Completion Date:
September 2017
Related Keywords:
- Hepatocellular Carcinoma
- Liver Cirrhosis
- Evidence of Liver Transplantation
- Hepatocellular carcinoma
- Cirrhosis
- Transplantation
- Carcinoma
- Liver Cirrhosis
- Fibrosis
- Recurrence
- Carcinoma, Hepatocellular
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