Know Cancer

forgot password

Randomized Phase III Trial Comparing Everolimus Plus Placebo Versus Everolimus Plus Bevacizumab for Advanced Renal Cell Carcinoma Progressing After Treatment With Tyrosine Kinase Inhibitors

Phase 3
18 Years
Open (Enrolling)
Clear Cell Renal Cell Carcinoma, Recurrent Renal Cell Cancer, Stage III Renal Cell Cancer, Stage IV Renal Cell Cancer

Thank you

Trial Information

Randomized Phase III Trial Comparing Everolimus Plus Placebo Versus Everolimus Plus Bevacizumab for Advanced Renal Cell Carcinoma Progressing After Treatment With Tyrosine Kinase Inhibitors


l. To compare the overall survival of patients receiving bevacizumab plus everolimus and
everolimus alone among patients with advanced renal cell carcinoma progressing after first
line VEGFR-TKI treatment.


I. To compare the progression-free survival and proportion who experience an objective
response (defined as cCR + PR) in patients with advanced renal cell carcinoma receiving
bevacizumab plus everolimus and everolimus alone.

II. To compare grade 3 or higher toxicity in patients receiving each treatment regimen.

OUTLINE: This is a multicenter study. Patients are stratified according to number of risk
factors (i.e., Karnofsky performance status < 80%, corrected serum calcium >= 10 mg/dL, and
hemoglobin =< 13 g/dL for male patients or =< 11.5 g/dL for female patients) present (0 vs 1
vs 2-3) and total duration of prior VEGFR tyrosine kinase inhibitor therapy (< 12 weeks vs
>= 12 weeks). Patients are randomized to 1 of 2 treatment arms.

ARM I: Patients receive everolimus orally (PO) once daily on days 1-28.

ARM II: Patients receive everolimus PO once daily on days 1-28 and bevacizumab intravenously
(IV) over 30-90 minutes on days 1 and 15.

In both arms, courses repeat every 28 days in the absence of disease progression or
unacceptable toxicity. Blood, urine, and tumor tissue samples may be collected periodically
for pharmacogenomic and correlative studies.

After completion of study treatment, patients are followed up every 8 weeks until disease
progression and then every 6 months for up to 5.5 years.

Inclusion Criteria:

- Histologically confirmed renal cell carcinoma

- Some component of clear cell disease

- Metastatic or unresectable disease

- Measurable disease by RECIST criteria, defined as lesions that can be accurately
measured in ≥ 1 dimension (longest diameter to be recorded) as ≥ 2 cm with
conventional techniques or as ≥ 1 cm with spiral CT scan

- Treated with ≥ 1 prior VEGFR tyrosine kinase inhibitor treatment and have progressed
or have been intolerant to treatment

- Available archive tissue for submission

- No active brain metastases

- Patients with treated, stable (for ≥ 3 months) brain metastases are eligible
provided that they meet the following criteria:

- No ongoing requirement for steroids

- No evidence of progression or hemorrhage after treatment for ≥ 3 months as
ascertained by clinical examination and brain imaging (MRI or CT scan)

- Stable doses of anticonvulsants are allowed

- Treatment may include whole-brain radiotherapy, radiosurgery (Gamma Knife,
LINAC, or equivalent), or a combination as deemed appropriate by the
treating physician

- Patients with CNS metastases treated by neurosurgical resection or brain
biopsy performed within the past 3 months are not eligible

- Baseline brain imaging (MRI or CT scan) is required

- ECOG performance status (PS) 0-2 OR Karnofsky PS 60-100%

- Granulocytes ≥ 1,500/mm^3

- Platelet count ≥ 100,000/mm^3

- Calculated creatinine clearance ≥ 30 mL/min

- Bilirubin ≤ 1.5 times upper limit of normal (ULN)

- AST ≤ 2.5 times ULN

- Fasting serum triglycerides ≤ 200 mg/dL

- Serum cholesterol ≤ 300 mg/dL

- Fasting serum glucose ≤ 1.5 times ULN

- Urine protein to creatinine ratio < 1.0 OR urine protein ≤ 1+

- Not pregnant or nursing

- Negative pregnancy test

- Fertile patients must use effective contraception during and for ≥ 6 months after
completion of study therapy

- No arterial thrombotic events within the past 6 months, including any of the

- Transient ischemic attack

- Cerebrovascular accident

- Peripheral arterial thrombus

- Unstable angina or angina requiring surgical or medical intervention within the
past 6 months

- Myocardial infraction

- Clinically significant peripheral artery disease (i.e., claudication on < 1

- Significant vascular disease (i.e., aortic aneurysm, history of aortic

- Any other arterial thrombotic event

- Patients who experienced a deep venous thrombosis or pulmonary embolus within the
past 6 months are eligible provided that they are on stable therapeutic

- No inadequately controlled hypertension (defined as a BP of ≥ 160 mm Hg systolic
and/or ≥ 90 mm Hg diastolic on medication) or any history of hypertensive crisis or
hypertensive encephalopathy

- No NYHA class II-IV congestive heart failure

- No known severe impairment of lung function, defined as dyspnea or cough ≥ grade 2
and meeting 1 of the following criteria:

- Requirement for supplemental oxygen

- In cases where pulmonary function or pulse oximetry tests have been obtained,
FEV1 or forced vital capacity is < 50% of predicted, or single breath DLCO is <
35% of predicted, or resting room oxygen saturation is < 90%

- No active or severe liver disease (e.g., acute or chronic hepatitis, cirrhosis)

- No positive serology for anti-hepatitis B core or anti-hepatitis C virus

- Hepatitis B virus (HBV) seropositive patients (HB surface antigen positive) are
eligible provided that they are closely monitored for evidence of active HBV
infection by HBV DNA testing and agree to receive suppressive therapy with
lamivudine or other HBV-suppressive therapy until ≥ 4 weeks after the last dose
of everolimus

- No active bleeding or chronic hemorrhagic diathesis or increased risk for bleeding
including, but not limited to, history of major bleeding within the past 6 months
(e.g., gastrointestinal [GI], lung, or CNS sites or required transfusion support)

- No abdominal fistula, GI perforation, or intra-abdominal abscess within the past 6

- No serious non-healing wound, ulcer, or bone fracture

- No significant traumatic injury within the past 4 weeks

- No concurrent hormones or other chemotherapeutic agents except for steroids given for
adrenal failure, suspected drug-induced pneumonitis, or other allergic reactions;
hormones administered for non-disease-related conditions (e.g., insulin for
diabetes); and intermittent use of dexamethasone as an antiemetic or to treat cough
associated with everolimus pneumonitis

- Concurrent antiplatelet agents and prophylactic anticoagulation allowed

- No prior systemic therapy with a VEGF-binding agent (e.g., bevacizumab)

- No prior systemic therapy with any mTOR inhibitor (e.g., sirolimus, temsirolimus,

- Prior cytokine therapy allowed

- At least 4 weeks since prior systemic therapy

- At least 4 weeks since prior major surgical procedure* or open biopsy and fully

- At least 2 weeks since prior radiotherapy (including palliative) and no concurrent

- A symptomatic lesion or one which may produce disability (e.g., unstable femur)
may be irradiated before study initiation, provided other measurable or
evaluable disease is present

- No concurrent immunosuppressive therapy, including chronic systemic treatment with
corticosteroids (≥ 10 mg/day prednisone equivalent)

Type of Study:


Study Design:

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment

Outcome Measure:

Overall survival (OS)

Outcome Description:

The stratified log-rank statistic will be the primary analysis to compare the two treatment arms on OS adjusting on the stratification factors (number of negative prognostic factors (0, 1, 2-3) and prior VEGFR-TKI therapy (< 12 weeks, >= 12 weeks). The Kaplan-Meier product-limit estimator will be used to estimate the OS distribution. In addition, the proportional hazards model will be used to assess the importance of the treatment arm adjusting on patient characteristics, stratification variables and other important covariates in predicting OS.

Outcome Time Frame:

The time from date of randomization to date of death due to any cause, assessed up to 6.5 years

Safety Issue:


Principal Investigator

George Philips

Investigator Role:

Principal Investigator

Investigator Affiliation:

Cancer and Leukemia Group B


United States: Food and Drug Administration

Study ID:




Start Date:

September 2010

Completion Date:

Related Keywords:

  • Clear Cell Renal Cell Carcinoma
  • Recurrent Renal Cell Cancer
  • Stage III Renal Cell Cancer
  • Stage IV Renal Cell Cancer
  • Carcinoma
  • Carcinoma, Renal Cell



Louisiana State University New Orleans, Louisiana  70112-2282
Johns Hopkins University Baltimore, Maryland  21205
University of Iowa Hospitals and Clinics Iowa City, Iowa  52242
University of Mississippi Medical Center Jackson, Mississippi  39216-4505
Washington University School of Medicine Saint Louis, Missouri  63110
Boulder Community Hospital Boulder, Colorado  80301-9019
Porter Adventist Hospital Denver, Colorado  80210
Rose Medical Center Denver, Colorado  80220
Swedish Medical Center Englewood, Colorado  80110
Sky Ridge Medical Center Lone Tree, Colorado  80124
North Suburban Medical Center Thornton, Colorado  80229
Bronson Methodist Hospital Kalamazoo, Michigan  49007
West Michigan Cancer Center Kalamazoo, Michigan  49007-3731
Borgess Medical Center Kalamazooaa, Michigan  49001
Fairview Ridges Hospital Burnsville, Minnesota  55337
Hutchinson Area Health Care Hutchinson, Minnesota  55350
United Hospital St. Paul, Minnesota  55102
Ridgeview Medical Center Waconia, Minnesota  55387
Geisinger Medical Center Danville, Pennsylvania  17822-0001
Avera Cancer Institute Sioux Falls, South Dakota  57105
Loyola University Medical Center Maywood, Illinois  60153
CentraCare Clinic Saint Cloud, Minnesota  56303
Henry Ford Hospital Detroit, Michigan  48202
Marshfield Clinic Marshfield, Wisconsin  54449
Sutter Health Western Division Cancer Research Group Greenbrae, California  94904
Methodist Medical Center of Illinois Peoria, Illinois  61636
Memorial Hospital of South Bend South Bend, Indiana  46601
Mary Bird Perkins Cancer Center Baton Rouge, Louisiana  70809
McLaren Regional Cancer Center Flint, Michigan  48432
Akron General Medical Center Akron, Ohio  44302
Lehigh Valley Hospital Allentown, Pennsylvania  18103
Dana-Farber Cancer Institute Boston, Massachusetts  02115
University of Arkansas for Medical Sciences Little Rock, Arkansas  72205
Hartford Hospital Hartford, Connecticut  06102-5037
Eastern Maine Medical Center Bangor, Maine  04401
Franklin Square Hospital Center Baltimore, Maryland  21237
Baystate Medical Center Springfield, Massachusetts  01199
Staten Island University Hospital Staten Island, New York  10305
University of Nebraska Medical Center Omaha, Nebraska  68198-3330
Kaiser Permanente Medical Center - Santa Clara Santa Clara, California  95051-5386
University of Oklahoma Health Sciences Center Oklahoma City, Oklahoma  73104
Legacy Emanuel Hospital and Health Center Portland, Oregon  97227
Iowa Methodist Medical Center Des Moines, Iowa  50309
Iowa Lutheran Hospital Des Moines, Iowa  50316-2301
Weill Medical College of Cornell University New York, New York  10021
Southern California Permanente Medical Group Downey, California  90242
Medical Center of Central Georgia Macon, Georgia  31201
Great Falls Clinic Great Falls, Montana  59405
Thompson Cancer Survival Center Knoxville, Tennessee  37916
Advocate Christ Medical Center Oak Lawn, Illinois  60453
Lewistown Hospital Lewistown, Pennsylvania  17044
Mount Nittany Medical Center State College, Pennsylvania  16803
Sibley Memorial Hospital Washington, District of Columbia  20016
North Colorado Medical Center Greeley, Colorado  80631
McKee Medical Center Loveland, Colorado  80539
Munson Medical Center Traverse City, Michigan  49684
Bozeman Deaconess Hospital Bozeman, Montana  59715
Big Sky Oncology Great Falls, Montana  59405
Kalispell Medical Oncology Kalispell, Montana  59901
Kalispell Regional Medical Center Kalispell, Montana  59901
Avera McKennan Hospital and University Health Center Sioux Falls, South Dakota  57105
Welch Cancer Center Sheridan, Wyoming  82801
Brigham and Women's Hospital Boston, Massachusetts  02115
Elkhart General Hospital Elkhart, Indiana  46515
South Bend Clinic South Bend, Indiana  46617
Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University Medical Center Columbus, Ohio  43210-1240
Front Range Cancer Specialists Fort Collins, Colorado  80528
University Medical Center of Southern Nevada Las Vegas, Nevada  89102
Alta Bates Summit Medical Center - Summit Campus Oakland, California  94609
Sutter Solano Medical Center Vallejo, California  94589
Poudre Valley Hospital Fort Collins, Colorado  80524
Beebe Medical Center Lewes, Delaware  19958
Memorial Hospital Carthage, Illinois  62321
Mason District Hospital Havana, Illinois  62644
McDonough District Hospital Macomb, Illinois  61455
BroMenn Regional Medical Center Normal, Illinois  61761
Proctor Hospital Peoria, Illinois  61614
Perry Memorial Hospital Princeton, Illinois  61356
Bay Regional Medical Center Bay City, Michigan  48708
Mecosta County Medical Center Big Rapids, Michigan  49307
Community Cancer Center of Monroe Monroe, Michigan  48162
Saint Francis Medical Center Cape Girardeau, Missouri  63701
Great Plains Regional Medical Center North Platte, Nebraska  69101-6598
Grandview Hospital Dayton, Ohio  45405
Lima Memorial Hospital Lima, Ohio  45804
Mercy Medical Center Springfield, Ohio  45504
Mercy Hospital of Tiffin Tiffin, Ohio  44883
Fulton County Health Center Wauseon, Ohio  43567
Legacy Mount Hood Medical Center Gresham, Oregon  97030
Legacy Meridian Park Hospital Tualatin, Oregon  97062
Mountainview Medical Berlin, Vermont  05602
Exempla Lutheran Medical Center Wheat Ridge, Colorado  80033
Eureka Hospital Eureka, Illinois  61530
Mercy Hospital Coon Rapids, Minnesota  55433
Allenmore Hospital Tacoma, Washington  98411-0414
Graham Hospital Association Canton, Illinois  61520
Holy Family Medical Center Des Plaines, Illinois  60016
Saint Joseph Medical Center Joliet, Illinois  60435
Medical Oncology and Hematology Associates Des Moines, Iowa  50309
Bixby Medical Center Adrian, Michigan  49221
Fairview-Southdale Hospital Edina, Minnesota  55435
Abbott-Northwestern Hospital Minneapolis, Minnesota  55407
Regions Hospital Saint Paul, Minnesota  55101
Saint Francis Regional Medical Center Shakopee, Minnesota  55379
Rice Memorial Hospital Willmar, Minnesota  56201
Saint Luke's Hospital Maumee, Ohio  43537
Geisinger Medical Group State College, Pennsylvania  16801
Highland General Hospital Oakland, California  94602
Swedish American Hospital Rockford, Illinois  61104
Saint Luke's Hospital Chesterfield, Missouri  63017
Miami Valley Hospital Dayton, Ohio  45409
Eastern Connecticut Hematology and Oncology Associates Norwich, Connecticut  06360
Menorah Medical Center Overland Park, Kansas  66209
Shawnee Mission Medical Center Shawnee Mission, Kansas  66204
North Kansas City Hospital Kansas City, Missouri  64116
Research Medical Center Kansas City, Missouri  64132
Saint Luke's East - Lee's Summit Lee's Summit, Missouri  64086
Liberty Hospital Liberty, Missouri  64068
Heartland Regional Medical Center Saint Joseph, Missouri  64506
Bozeman Deaconess Cancer Center Bozeman, Montana  59715
Northern Montana Hospital Havre, Montana  59501
Wayne Hospital Greenville, Ohio  45331
Fisher-Titus Medical Center Norwalk, Ohio  44857
Clinton Memorial Hospital Wilmington, Ohio  45177
Providence Centralia Hospital Centralia, Washington  98531-9027
Marshfield Clinic Cancer Care at Regional Cancer Center Eau Claire, Wisconsin  54701
Marshfield Clinic - Weston Center Weston, Wisconsin  54476
Diagnostic and Treatment Center Weston, Wisconsin  54476
Marshfield Clinic - Wisconsin Rapids Center Wisconsin Rapids, Wisconsin  54494
Rocky Mountain Oncology Casper, Wyoming  82609
Longmont United Hospital Longmont, Colorado  80501
Greene Memorial Hospital Xenia, Ohio  45385
Greater Baltimore Medical Center Baltimore, Maryland  21204
Harold Alfond Center for Cancer Care Augusta, Maine  04330
Union Hospital of Cecil County Elkton MD, Maryland  21921
Cancer Centers of the Carolinas - Grove Commons Greenville, South Carolina  29605
Cancer Centers of the Carolinas - Seneca Seneca, South Carolina  29672
Cancer Centers of the Carolinas - Spartanburg Spartanburg, South Carolina  29307
Mayo Clinic in Arizona Scottsdale, Arizona  85259-5404
Washington Hospital Center Washington, District of Columbia  20010
Memorial Medical Center Springfield, Illinois  62781
Phelps County Regional Medical Center Rolla, Missouri  65401
Saint Francis Medical Center Grand Island, Nebraska  68802
Wellmont Holston Valley Hospital and Medical Center Kingsport, Tennessee  37662
La Grange Memorial Hospital La Grange, Illinois  60525
Metro Health Hospital Grand Rapids, Michigan  49506
University of North Carolina Chapel Hill, North Carolina  27599
Providence Medical Center Kansas City, Kansas  66112
Lynchburg Hematology-Oncology Clinic Lynchburg, Virginia  24501
Northwest Cancer Specialists Vancouver, Washington  98664
East Bay Radiation Oncology Center Castro Valley, California  94546
Contra Costa Regional Medical Center Martinez, California  94553-3156
Memorial Medical Center Modesto, California  95355
Larry G Strieff MD Medical Corporation Oakland, California  94609
Hennepin County Medical Center Minneapolis, Minnesota  
Glens Falls Hospital Glens Falls, New York  12801
Holy Cross Hospital Fort Lauderdale, Florida  33308
El Camino Hospital Mountain View, California  94040
Cleveland Clinic Florida - Weston Weston, Florida  33331
University of California at San Diego La Jolla, California  92093
Wayne State University Detroit, Michigan  48202
Kaiser Permanente Medical Center Vallejo, California  94589
University of Massachusetts Medical School Worcester, Massachusetts  01605
California Pacific Medical Center San Francisco, California  94115
Mid Dakota Clinic Bismarck, North Dakota  58501
Weiss Memorial Hospital Chicago,, Illinois  60640
University Of Vermont Burlington,, Vermont  05403
Presbyterian - Saint Lukes Medical Center - Health One Denver, Colorado  80218
Sacred Heart Hospital Pensacola, Florida  32503
Kaiser Permanente Sacramento, California  
University of Kentucky Lexington, Kentucky  40536-0098
Montana Cancer Consortium CCOP Billings, Montana  59101
Flower Hospital Sylvania, Ohio  43560-2197
Huntsman Cancer Institute/University of Utah Salt Lake City, Utah  84112
Metro-Minnesota CCOP St. Louis Park, Minnesota  
Cancer Centers of the Carolinas - Easley Easley, South Carolina  29640
Lakeview Hospital Stillwater, Minnesota  55082
Decatur Memorial Hospital Decatur, Illinois  62526
Louisiana State University Health Science Center New Orleans, Louisiana  70112
Virginia Commonwealth University Richmond, Virginia  
Kaiser Permanente Portland, Oregon  97227
Montana Cancer Specialists Missoula, Montana  59807-7877
Florida Hospital Orlando, Florida  32803
Memorial Health University Medical Center Savannah, Georgia  31404
University of Chicago Comprehensive Cancer Center Chicago, Illinois  60637-1470
Northern Indiana Cancer Research Consortium South Bend, Indiana  
Rockwood Clinic Spokane, Washington  99220
Rohnert Park Cancer Center Rohnert Park, California  94928
South Sacramento Cancer Center Sacramento, California  95823
University of Cincinnati Cincinnati, Ohio  45267-0502
Penn State Milton S Hershey Medical Center Hershey, Pennsylvania  17033
Southeast Cancer Center Cape Girardeau, Missouri  63703
Butler Memorial Hospital Butler, Pennsylvania  16001
Littleton Adventist Hospital Littleton, Colorado  80122
Parker Adventist Hospital Parker, Colorado  80138
New Ulm Medical Center New Ulm, Minnesota  56073
OSF Saint Francis Medical Center Peoria, Illinois  61637
Mills - Peninsula Hospitals Burlingame, California  94010
Valley Medical Oncology Consultants-Castro Valley Castro Valley, California  94546
Valley Medical Oncology Consultants-Fremont Fremont, California  94538
Kaiser Permanente, Fremont Fremont, California  94538
Kaiser Permanente, Hayward Hayward, California  94545
Bay Area Breast Surgeons Inc Oakland, California  94609
Bay Area Tumor Institution CCOP Oakland, California  94609
Tom K Lee Inc Oakland, California  94609
Kaiser Permanente-Oakland Oakland, California  94611
Kaiser Permanente-Redwood City Redwood City, California  94063
Kaiser Permanente-Richmond Richmond, California  94801
Kaiser Permanente-Roseville Roseville, California  95661
Kaiser Permanente-South Sacramento Sacramento, California  95823
Kaiser Permanente - Sacramento Sacramento, California  95825
Kaiser Permanente-San Francisco San Francisco, California  94115
University of California San Francisco Medical Center-Mount Zion San Francisco, California  94115
Kaiser Permanente-Santa Teresa-San Jose San Jose, California  95119
Doctors Medical Center- JC Robinson Regional Cancer Center San Pablo, California  94806
Kaiser Permanente-San Rafael San Rafael, California  94903
Kaiser Permanente-Santa Rosa Santa Rosa, California  95403
Kaiser Permanente-South San Francisco South San Francisco, California  94080
Kaiser Permanente-Stockton Stockton, California  95210
Kaiser Permanente-Vallejo Vallejo, California  94589
Kaiser Permanente-Walnut Creek Walnut Creek, California  94596
The Medical Center of Aurora Aurora, Colorado  80012
Penrose-Saint Francis Healthcare Colorado Springs, Colorado  80907
Saint Anthony Central Hospital Denver, Colorado  80204
Exempla Saint Joseph Hospital Denver, Colorado  80218
Colorado Cancer Research Program CCOP Denver, Colorado  80224-2522
Saint Mary's Hospital and Regional Medical Center Grand Junction, Colorado  81502
Saint Mary Corwin Medical Center Pueblo, Colorado  81004
The Hospital of Central Connecticut New Britain, Connecticut  06050
Stamford Hospital Stamford, Connecticut  06904
Lombardi Comprehensive Cancer Center at Georgetown University Washington, District of Columbia  20057
M D Anderson Cancer Center- Orlando Orlando, Florida  32806
Sacred Heart Medical Oncology Group - Davis Highway Pensacola, Florida  32514
Phoebe Putney Memorial Hospital Albany, Georgia  31703
Saint Luke's Mountain States Tumor Institute Boise, Idaho  83712
John H Stroger Jr Hospital of Cook County Chicago, Illinois  60612-3785
Resurrection Healthcare Chicago, Illinois  60631
Provena Saint Mary's Hospital Kankakee, Illinois  60901
Good Samaritan Regional Medical Center Mt. Vernon, Illinois  62864
Community Cancer Center Foundation Normal, Illinois  61761
Illinois CancerCare-Ottawa Clinic Ottawa, Illinois  61350
Ottawa Regional Hospital and Healthcare Center Ottawa, Illinois  61350
Pekin Cancer Treatment Center Pekin, Illinois  61554
Illinois Oncology Research Association CCOP Peoria, Illinois  61615
Illinois CancerCare-Peoria Peoria, Illinois  61615
Illinois Valley Hospital Peru, Illinois  61354
West Suburban Cancer Center River Forest, Illinois  60305
Reid Hospital and Health Care Services Richmond, Indiana  47374
Hematology Oncology Associates-Quad Cities Bettendorf, Iowa  52722
Cedar Rapids Oncology Association Cedar Rapids, Iowa  52403
Iowa Blood and Cancer Care PLC Cedar Rapids, Iowa  52402
Mercy Hospital Cedar Rapids, Iowa  52403
Saint Luke's Hospital Cedar Rapids, Iowa  52402
Medical Oncology and Hematology Associates-West Des Moines Clive, Iowa  50325
Iowa Oncology Research Association CCOP Des Moines, Iowa  50309
Mercy Medical Center - Des Moines Des Moines, Iowa  50314
Medical Oncology and Hematology Associates-Des Moines Des Moines, Iowa  50309
Mercy Medical Center-Sioux City Sioux City, Iowa  51104
Saint Luke's Regional Medical Center Sioux City, Iowa  51104
Stormont-Vail Regional Health Center Topeka, Kansas  66604
Louisiana State University Sciences Center- Monroe Monroe, Louisiana  71210
Medical Center of Louisiana New Orleans, Louisiana  70112
Highland Clinic Shreveport, Louisiana  71105
Caritas Saint Elizabeth's Medical Center Brighton, Massachusetts  02135-2997
Berkshire Hematology Oncology PC Pittsfield, Massachusetts  01201
Hickman Cancer Center Adrian, Michigan  49221
Green Bay Oncology - Escanaba Escanaba, Michigan  49431
Grand Rapids Clinical Oncology Program Grand Rapids, Michigan  49503
Saint Mary's Health Care Grand Rapids, Michigan  49503
Spectrum Health at Butterworth Campus Grand Rapids, Michigan  49503
Green Bay Oncology - Iron Mountain Iron Mountain, Michigan  49801
Mercy Memorial Hospital Monroe, Michigan  48162
Mercy Health Partners-Mercy Campus Muskegon, Michigan  49443
Northern Michigan Regional Hospital Petoskey, Michigan  49770
Lakeland Hospital St. Joseph, Michigan  49085
Medini, Eitan MD (UIA Investigator) Alexandria, Minnesota  56308
Unity Hospital Fridley, Minnesota  55432
Saint John's Hospital - Healtheast Maplewood, Minnesota  55109
Minnesota Oncology Hematology PA-Maplewood Maplewood, Minnesota  55109
Minneapolis Veterans Medical Center Minneapolis, Minnesota  55417
North Memorial Medical Health Center Robbinsdale, Minnesota  55422
Saint Cloud Hospital Saint Cloud, Minnesota  56303
Park Nicollet Clinic - Saint Louis Park Saint Louis Park, Minnesota  55416
Minnesota Oncology and Hematology PA-Woodbury Woodbury, Minnesota  55125
Saint John's Regional Medical Center Joplin, Missouri  64804
Freeman Health System Joplin, Missouri  64804
Saint Luke's Cancer Institute Kansas City, Missouri  64111
Saint Luke's Hospital of Kansas City Kansas City, Missouri  64111
Saint Joseph Health Center Kansas City, Missouri  64114
Liberty Radiation Oncology Clinic Kansas City, Missouri  64116
Truman Medical Center Kansas City, Missouri  64108
Saint Louis-Cape Girardeau CCOP Saint Louis, Missouri  63141
Missouri Baptist Medical Center Saint Louis, Missouri  63131
Saint John's Mercy Medical Center Saint Louis, Missouri  63141
Ozark Health Ventures LLC dba Cancer Research for The Ozarks Springfield Springfield, Missouri  65802
Saint John's Hospital Springfield, Missouri  65804
Cox Medical Center Springfield, Missouri  65807
Hematology-Oncology Centers of the Northern Rockies PC Billings, Montana  59101
Saint Vincent Healthcare Billings, Montana  59101
Billings Clinic Billings, Montana  59107-7000
Saint James Community Hospital and Cancer Treatment Center Butte, Montana  59701
Benefis Healthcare- Sletten Cancer Institute Great Falls, Montana  59405
Saint Peter's Community Hospital Helena, Montana  59601
Glacier Oncology PLLC Kalispell, Montana  59901
Saint Patrick Hospital - Community Hospital Missoula, Montana  59802
Good Samaritan Hospital Kearney, Nebraska  68847
Nevada Cancer Research Foundation CCOP Las Vegas, Nevada  89106
Cooper Hospital University Medical Center Camden, New Jersey  08103
Fox Chase Cancer Center at Virtua Memorial Hospital of Burlington County Mount Holly, New Jersey  08060
Virtua West Jersey Hospital Voorhees Voorhees, New Jersey  08043
Veterans Affairs Western New York Health Care System-Buffalo Buffalo, New York  14215
Orange Regional Medical Center Middletown, New York  10940
State University of New York Upstate Medical University Syracuse, New York  13210
Mission Hospitals Inc Asheville, North Carolina  28801
Wayne Memorial Hospital Goldsboro, North Carolina  27534
Margaret R Pardee Memorial Hospital Hendersonville, North Carolina  28791
Kinston Medical Specialists PA Kinston, North Carolina  28501
Marion L Shepard Cancer Center Washington, North Carolina  27889
Saint Alexius Medical Center Bismarck, North Dakota  58501
Summa Barberton Hospital Barberton, Ohio  44203
Good Samaritan Hospital - Dayton Dayton, Ohio  45406
Dayton CCOP Dayton, Ohio  45429
Samaritan North Health Center Dayton, Ohio  45415
Hematology Oncology Center Incorporated Elyria, Ohio  44035
Blanchard Valley Hospital Findlay, Ohio  45840
Atrium Medical Center-Middletown Regional Hospital Franklin, Ohio  45005-1066
Kettering Medical Center Kettering, Ohio  45429
Saint Rita's Medical Center Lima, Ohio  45801
Toledo Radiation Oncology at Northwest Ohio Onocolgy Center Maumee, Ohio  43537
Saint Charles Hospital Oregon, Ohio  43616
North Coast Cancer Care Sandusky, Ohio  44870
Toledo Community Hospital Oncology Program CCOP Toledo, Ohio  43617
Mercy Cancer Center at Saint Anne Mercy Hospital Toledo, Ohio  43623
University of Toledo Toledo, Ohio  43614
Saint Vincent Mercy Medical Center Toledo, Ohio  43608
Upper Valley Medical Center Troy, Ohio  45373
Wright-Patterson Medical Center Wright-Patterson Afb, Ohio  45433-5529
Legacy Good Samaritan Hospital and Medical Center Portland, Oregon  97210
Northwest Cancer Specialists-Rose Quarter Cancer Center Portland, Oregon  97227
Ephrata Cancer Center Ephrata, Pennsylvania  17522
Riddle Hospital Media, Pennsylvania  19063
Hematology and Oncology Associates of North East Pennsylvania Scranton, Pennsylvania  18508
Associates In Hematology Oncology PC-Upland Upland, Pennsylvania  19013
Geisinger Wyoming Valley Wilkes-Barre, Pennsylvania  18711
Greenville Memorial Hospital Greenville, South Carolina  29605
Fredericksburg Oncology Inc Fredericksburg, Virginia  22401
Southwest VA Regional Cancer Center Norton, Virginia  24273
Saint Francis Hospital Federal Way, Washington  98003
Providence - Saint Peter Hospital Olympia, Washington  98506-5166
Good Samaritan Community Hospital Puyallup, Washington  98372
Northwest CCOP Tacoma, Washington  98405
Multicare Health System Tacoma, Washington  98415
Saint Clare Hospital Tacoma, Washington  98499
Saint Joseph Medical Center Tacoma, Washington  98405
Langlade Hospital and Cancer Center Antigo, Wisconsin  54409
Saint Vincent Hospital Green Bay, Wisconsin  54301
Green Bay Oncology Limited at Saint Mary's Hospital Green Bay, Wisconsin  54303
Saint Mary's Hospital Green Bay, Wisconsin  54303
Green Bay Oncology at Saint Vincent Hospital Green Bay, Wisconsin  54301-3526
Bay Area Medical Center Marinette, Wisconsin  54143
Marshfield Clinic-Minocqua Center Minocqua, Wisconsin  54548
Green Bay Oncology - Oconto Falls Oconto Falls, Wisconsin  54154
Marshfield Clinic at James Beck Cancer Center Rhinelander, Wisconsin  54501
Marshfield Clinic-Rice Lake Center Rice Lake, Wisconsin  54868
Green Bay Oncology - Sturgeon Bay Sturgeon Bay, Wisconsin  54235
Aspirus Regional Cancer Center Wausau, Wisconsin  54401
Jupiter Medical Center Jupiter, Florida  33458
University of Illinois Chicago, Illinois  60612
Lahey Clinic Medical Center Burlington, Massachusetts  01805
Elkhart Clinic Elkhart, Indiana  46515
Mount Sinai Medical Center CCOP Miami Beach, Florida  33140
Illinois CancerCare-Bloomington Bloomington%, Illinois  61701
Illinois CancerCare-Canton Canton, Illinois  61520
Illinois CancerCare-Carthage Carthage, Illinois  62321
Jesse Brown Veterans Affairs Medical Center Chicago, Illinois  60612
Illinois CancerCare-Eureka Eureka, Illinois  61530
Illinois CancerCare-Havana Havana, Illinois  62644
Illinois CancerCare-Kewanee Clinic Kewanee, Illinois  61443
Illinois CancerCare-Macomb Macomb, Illinois  61455
Illinois CancerCare-Monmouth Monmouth, Illinois  61462
Illinois CancerCare-Community Cancer Center Normal, Illinois  61761
Illinois CancerCare-Pekin Pekin, Illinois  61603
Illinois CancerCare-Peru Peru, Illinois  61354
Illinois CancerCare-Princeton Princeton, Illinois  61356
Illinois CancerCare-Spring Valley Spring Valley, Illinois  61362
Michiana Hematology Oncology PC-Elkhart Elkhart, Indiana  46514
Michiana Hematology Oncology PC-Plymouth Plymouth, Indiana  46563
Michiana Hematology Oncology PC-South Bend South Bend, Indiana  46601
Michiana Hematology Oncology-PC Westville Westville, Indiana  46391
Michiana Hematology Oncology PC-Niles Niles, Michigan  49120
Central Care Cancer Center-Carrie J Babb Cancer Center Bolivar, Missouri  65613
Skaggs Cancer Center Branson, Missouri  65616
University of Missouri - Ellis Fischel Columbia, Missouri  65203
North Coast Cancer Care-Clyde Clyde, Ohio  43410
Community Health Partners Regional Medical Center Elyria, Ohio  44035
Roper Hospital Charleston, South Carolina  29401
Cancer Centers of the Carolinas - Faris Greenville, South Carolina  29605
Cancer Centers of the Carolinas-Greer Medical Oncology Greer, South Carolina  29650
University of Tennessee - Knoxville Knoxville, Tennessee  37920
West Virginia University Charleston Charleston, West Virginia  25304
Marshfield Clinic-Chippewa Center Chippewa Falls, Wisconsin  54729
Holy Family Memorial Hospital Manitowoc, Wisconsin  54221
Marshfield Clinic Cancer Care at Saint Michael's Hospital Stevens Point, Wisconsin  54481
Riverview Hospital Wisconsin Rapids, Wisconsin  54494
Cancer Centers of Southwest Oklahoma Research Lawton, Oklahoma  
Saint Luke's Mountain States Tumor Institute - Fruitland Fruitland, Idaho  83619
Kaiser Anaheim Medical Center Anaheim, California  92807
Kaiser Permanente-Deer Valley Medical Center Antioch, California  94531
Kaiser Permanente Medical Group - Baldwin Park Baldwin Park, California  91706
Kaiser Foundation Hospital Bellflower, California  90706
Kaiser Permanente Hospital Fontana, California  92335
Kaiser Permanente - Harbor City Harbor City, California  90710
Kaiser Permanente-West Los Angeles Los Angeles, California  90034
Epic Care-Oakland Oakland, California  94612
Kaiser Permanente Oakland-Broadway Oakland, California  94611
Kaiser Permanente - Panorama City Panorama City, California  91402
Palchak David MD Pismo Beach, California  93449
Kaiser Permanente-Rancho Cordova Cancer Center Rancho Cardova, California  95670
The Permanente Medical Group-Roseville Radiation Oncology Roseville, California  95678
Kaiser Permanente at San Diego San Diego, California  92120
Kaiser Permanente Health Care San Marcos, California  92069
Kaiser Permanente Cancer Treatment Center South San Francisco, California  94080
Kaiser Permanente Medical Center-Vacaville Vacaville, California  95688
Kaiser Permanente-Rock Creek Lafayette, Colorado  80026
Kaiser Permanente Moanalua Medical Center Honolulu, Hawaii  96819
Saint Luke's Mountain States Tumor Institute - Meridian Meridian, Idaho  83642
Saint Luke's Mountain States Tumor Institute - Nampa Nampa, Idaho  83686
Saint Luke's South Hospital Overland Park, Kansas  66213
Kansas City CCOP Prairie Village, Kansas  66208
Singh and Arora Hematology Oncology PC Flint, Michigan  48532
Great Lakes Cancer Institute-Lapeer Campus Lapeer, Michigan  48446
Mount Clemens Regional Medical Center Mount Clemens, Michigan  48043
Spectrum Health Reed City Hospital Reed City, Michigan  49677
Capital Region Medical Center-Goldschmidt Cancer Center Jefferson City, Missouri  65109
Heartland Hematology and Oncology Associates Incorporated Kansas City, Missouri  64118
Saint John's Clinic-Rolla-Cancer and Hematology Rolla, Missouri  65401
Saint Joseph Oncology Inc Saint Joseph, Missouri  64507
Comprehensive Cancer Care PC Saint Louis, Missouri  63141
Cancer Care Associates-Mercy Oklahoma City, Oklahoma  73120
Mid-Columbia Medical Center The Dalles, Oregon  97058
Susquehanna Cancer Center Williamsport, Pennsylvania  17701
Legacy Salmon Creek Hospital Vancouver, Washington  98686
Gundersen Lutheran La Crosse, Wisconsin  54601
Saint Nicholas Hospital Madison, Wisconsin  53715
San Francisco General Hospital San Francisco, California  94110
Kaiser Permanente-Franklin Denver, Colorado  80205
Siouxland Hematology Oncology Associates Sioux City, Iowa  51101
Walter Reed National Military Medical Center Bethesda, Maryland  20889
VA Medical Center - University of Iowa Iowa City, Iowa  52246
Methodist West Hospital West Des Moines, Iowa  50266-7700
Radiation Oncology Associates PC Fort Wayne, Indiana  46804
Alta Bates Summit Medical Center-Herrick Campus Berkeley, California  94704
Carle Foundation - Carle Cancer Center Urbana, Illinois  61801
Michiana Hematology Oncology PC-Mishawaka Mishawaka, Indiana  46545-1470
Oncology Associates at Mercy Medical Center Cedar Rapids, Iowa  52403
Marie Yeager Cancer Center Saint Joseph, Michigan  49085
Hematology Oncology Associates of Central New York PC East Syracuse, New York  13057
Summa Akron City Hospital Akron, Ohio  44304
Franciscan St. Francis Health Indianapolis, Indiana  46237
The Toledo Hospital/Toledo Children's Hospital Toledo, Ohio  43606
Sanford Bismarck Medical Center Bismarck, North Dakota  58501
Toledo Clinic Cancer Centers-Oregon Oregon, Ohio  43616
Geisinger Medical Center-Cancer Center Hazelton Hazleton, Pennsylvania  18201
Community Howard Regional Health Kokomo, Indiana  46904
Indiana University Health La Porte Hospital La Porte, Indiana  46350
Saint Joseph Regional Medical Center-Mishawaka Mishawaka, Indiana  46545-1470
Aurora Cancer Care-Milwaukee West Wauwatosa, Wisconsin  53226
Christiana Care Health System-Christiana Hospital Newark, Delaware  19718
Bronson Battle Creek Battle Creek, Michigan  49017
Saint Louis Cancer and Breast Institute-South City Saint Louis, Missouri  63109
Toledo Clinic Cancer Centers-Bowling Green Bowling Green, Ohio  43402
Toledo Clinic Cancer Centers-Maumee Maumee, Ohio  43537-1839
Toledo Clinic Cancer Centers-Toledo Toledo, Ohio  43623
Guthrie Clinic-Robert Packer Hospital Sayre, Pennsylvania  18840
Self Regional Healthcare Greenwood, South Carolina  29646
Sutter Pacific Medical Foundation Santa Rosa, California  95403
NEA Baptist Clinic-Matthews Jonesboro, Arkansas  72401
Saint Luke's Mountain States Tumor Institute-Twin Falls Twin Falls, Idaho  83301
Cancer Care Associates-Norman Norman, Oklahoma  73071
Mercy Physicians of Oklahoma-Lakeside Oklahoma City, Oklahoma  73120
Mercy Cancer Center-West Lakes Clive, Iowa  50325
Mercy Medical Center-West Lakes West Des Moines, Iowa  50266
White River Junction Veteran Administration Medical Center White River Junction, Vermont  05009