Know Cancer

forgot password

Randomized Phase III Trial Comparing Everolimus Plus Placebo Versus Everolimus Plus Bevacizumab for Advanced Renal Cell Carcinoma Progressing After Treatment With Tyrosine Kinase Inhibitors

Phase 3
18 Years
Open (Enrolling)
Clear Cell Renal Cell Carcinoma, Recurrent Renal Cell Cancer, Stage III Renal Cell Cancer, Stage IV Renal Cell Cancer

Thank you

Trial Information

Randomized Phase III Trial Comparing Everolimus Plus Placebo Versus Everolimus Plus Bevacizumab for Advanced Renal Cell Carcinoma Progressing After Treatment With Tyrosine Kinase Inhibitors


l. To compare the overall survival of patients receiving bevacizumab plus everolimus and
everolimus alone among patients with advanced renal cell carcinoma progressing after first
line VEGFR-TKI treatment.


I. To compare the progression-free survival and proportion who experience an objective
response (defined as cCR + PR) in patients with advanced renal cell carcinoma receiving
bevacizumab plus everolimus and everolimus alone.

II. To compare grade 3 or higher toxicity in patients receiving each treatment regimen.

OUTLINE: This is a multicenter study. Patients are stratified according to number of risk
factors (i.e., Karnofsky performance status < 80%, corrected serum calcium >= 10 mg/dL, and
hemoglobin =< 13 g/dL for male patients or =< 11.5 g/dL for female patients) present (0 vs 1
vs 2-3) and total duration of prior VEGFR tyrosine kinase inhibitor therapy (< 12 weeks vs
>= 12 weeks). Patients are randomized to 1 of 2 treatment arms.

ARM I: Patients receive everolimus orally (PO) once daily on days 1-28.

ARM II: Patients receive everolimus PO once daily on days 1-28 and bevacizumab intravenously
(IV) over 30-90 minutes on days 1 and 15.

In both arms, courses repeat every 28 days in the absence of disease progression or
unacceptable toxicity. Blood, urine, and tumor tissue samples may be collected periodically
for pharmacogenomic and correlative studies.

After completion of study treatment, patients are followed up every 8 weeks until disease
progression and then every 6 months for up to 5.5 years.

Inclusion Criteria:

- Histologically confirmed renal cell carcinoma

- Some component of clear cell disease

- Metastatic or unresectable disease

- Measurable disease by RECIST criteria, defined as lesions that can be accurately
measured in ≥ 1 dimension (longest diameter to be recorded) as ≥ 2 cm with
conventional techniques or as ≥ 1 cm with spiral CT scan

- Treated with ≥ 1 prior VEGFR tyrosine kinase inhibitor treatment and have progressed
or have been intolerant to treatment

- Available archive tissue for submission

- No active brain metastases

- Patients with treated, stable (for ≥ 3 months) brain metastases are eligible
provided that they meet the following criteria:

- No ongoing requirement for steroids

- No evidence of progression or hemorrhage after treatment for ≥ 3 months as
ascertained by clinical examination and brain imaging (MRI or CT scan)

- Stable doses of anticonvulsants are allowed

- Treatment may include whole-brain radiotherapy, radiosurgery (Gamma Knife,
LINAC, or equivalent), or a combination as deemed appropriate by the
treating physician

- Patients with CNS metastases treated by neurosurgical resection or brain
biopsy performed within the past 3 months are not eligible

- Baseline brain imaging (MRI or CT scan) is required

- ECOG performance status (PS) 0-2 OR Karnofsky PS 60-100%

- Granulocytes ≥ 1,500/mm^3

- Platelet count ≥ 100,000/mm^3

- Calculated creatinine clearance ≥ 30 mL/min

- Bilirubin ≤ 1.5 times upper limit of normal (ULN)

- AST ≤ 2.5 times ULN

- Fasting serum triglycerides ≤ 200 mg/dL

- Serum cholesterol ≤ 300 mg/dL

- Fasting serum glucose ≤ 1.5 times ULN

- Urine protein to creatinine ratio < 1.0 OR urine protein ≤ 1+

- Not pregnant or nursing

- Negative pregnancy test

- Fertile patients must use effective contraception during and for ≥ 6 months after
completion of study therapy

- No arterial thrombotic events within the past 6 months, including any of the

- Transient ischemic attack

- Cerebrovascular accident

- Peripheral arterial thrombus

- Unstable angina or angina requiring surgical or medical intervention within the
past 6 months

- Myocardial infraction

- Clinically significant peripheral artery disease (i.e., claudication on < 1

- Significant vascular disease (i.e., aortic aneurysm, history of aortic

- Any other arterial thrombotic event

- Patients who experienced a deep venous thrombosis or pulmonary embolus within the
past 6 months are eligible provided that they are on stable therapeutic

- No inadequately controlled hypertension (defined as a BP of ≥ 160 mm Hg systolic
and/or ≥ 90 mm Hg diastolic on medication) or any history of hypertensive crisis or
hypertensive encephalopathy

- No NYHA class II-IV congestive heart failure

- No known severe impairment of lung function, defined as dyspnea or cough ≥ grade 2
and meeting 1 of the following criteria:

- Requirement for supplemental oxygen

- In cases where pulmonary function or pulse oximetry tests have been obtained,
FEV1 or forced vital capacity is < 50% of predicted, or single breath DLCO is <
35% of predicted, or resting room oxygen saturation is < 90%

- No active or severe liver disease (e.g., acute or chronic hepatitis, cirrhosis)

- No positive serology for anti-hepatitis B core or anti-hepatitis C virus

- Hepatitis B virus (HBV) seropositive patients (HB surface antigen positive) are
eligible provided that they are closely monitored for evidence of active HBV
infection by HBV DNA testing and agree to receive suppressive therapy with
lamivudine or other HBV-suppressive therapy until ≥ 4 weeks after the last dose
of everolimus

- No active bleeding or chronic hemorrhagic diathesis or increased risk for bleeding
including, but not limited to, history of major bleeding within the past 6 months
(e.g., gastrointestinal [GI], lung, or CNS sites or required transfusion support)

- No abdominal fistula, GI perforation, or intra-abdominal abscess within the past 6

- No serious non-healing wound, ulcer, or bone fracture

- No significant traumatic injury within the past 4 weeks

- No concurrent hormones or other chemotherapeutic agents except for steroids given for
adrenal failure, suspected drug-induced pneumonitis, or other allergic reactions;
hormones administered for non-disease-related conditions (e.g., insulin for
diabetes); and intermittent use of dexamethasone as an antiemetic or to treat cough
associated with everolimus pneumonitis

- Concurrent antiplatelet agents and prophylactic anticoagulation allowed

- No prior systemic therapy with a VEGF-binding agent (e.g., bevacizumab)

- No prior systemic therapy with any mTOR inhibitor (e.g., sirolimus, temsirolimus,

- Prior cytokine therapy allowed

- At least 4 weeks since prior systemic therapy

- At least 4 weeks since prior major surgical procedure* or open biopsy and fully

- At least 2 weeks since prior radiotherapy (including palliative) and no concurrent

- A symptomatic lesion or one which may produce disability (e.g., unstable femur)
may be irradiated before study initiation, provided other measurable or
evaluable disease is present

- No concurrent immunosuppressive therapy, including chronic systemic treatment with
corticosteroids (≥ 10 mg/day prednisone equivalent)

Type of Study:


Study Design:

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment

Outcome Measure:

Overall survival (OS)

Outcome Description:

The stratified log-rank statistic will be the primary analysis to compare the two treatment arms on OS adjusting on the stratification factors (number of negative prognostic factors (0, 1, 2-3) and prior VEGFR-TKI therapy (< 12 weeks, >= 12 weeks). The Kaplan-Meier product-limit estimator will be used to estimate the OS distribution. In addition, the proportional hazards model will be used to assess the importance of the treatment arm adjusting on patient characteristics, stratification variables and other important covariates in predicting OS.

Outcome Time Frame:

The time from date of randomization to date of death due to any cause, assessed up to 6.5 years

Safety Issue:


Principal Investigator

George Philips

Investigator Role:

Principal Investigator

Investigator Affiliation:

Cancer and Leukemia Group B


United States: Food and Drug Administration

Study ID:




Start Date:

September 2010

Completion Date:

Related Keywords:

  • Clear Cell Renal Cell Carcinoma
  • Recurrent Renal Cell Cancer
  • Stage III Renal Cell Cancer
  • Stage IV Renal Cell Cancer
  • Carcinoma
  • Carcinoma, Renal Cell



Louisiana State UniversityNew Orleans, Louisiana  70112-2282
Johns Hopkins UniversityBaltimore, Maryland  21205
University of Iowa Hospitals and ClinicsIowa City, Iowa  52242
University of Mississippi Medical CenterJackson, Mississippi  39216-4505
Washington University School of MedicineSaint Louis, Missouri  63110
Boulder Community HospitalBoulder, Colorado  80301-9019
Porter Adventist HospitalDenver, Colorado  80210
Rose Medical CenterDenver, Colorado  80220
Swedish Medical CenterEnglewood, Colorado  80110
Sky Ridge Medical CenterLone Tree, Colorado  80124
North Suburban Medical CenterThornton, Colorado  80229
Bronson Methodist HospitalKalamazoo, Michigan  49007
West Michigan Cancer CenterKalamazoo, Michigan  49007-3731
Borgess Medical CenterKalamazooaa, Michigan  49001
Fairview Ridges HospitalBurnsville, Minnesota  55337
Hutchinson Area Health CareHutchinson, Minnesota  55350
United HospitalSt. Paul, Minnesota  55102
Ridgeview Medical CenterWaconia, Minnesota  55387
Geisinger Medical CenterDanville, Pennsylvania  17822-0001
Avera Cancer InstituteSioux Falls, South Dakota  57105
Loyola University Medical CenterMaywood, Illinois  60153
CentraCare ClinicSaint Cloud, Minnesota  56303
Henry Ford HospitalDetroit, Michigan  48202
Marshfield ClinicMarshfield, Wisconsin  54449
Sutter Health Western Division Cancer Research GroupGreenbrae, California  94904
Methodist Medical Center of IllinoisPeoria, Illinois  61636
Memorial Hospital of South BendSouth Bend, Indiana  46601
Mary Bird Perkins Cancer CenterBaton Rouge, Louisiana  70809
McLaren Regional Cancer CenterFlint, Michigan  48432
Akron General Medical CenterAkron, Ohio  44302
Lehigh Valley HospitalAllentown, Pennsylvania  18103
Dana-Farber Cancer InstituteBoston, Massachusetts  02115
University of Arkansas for Medical SciencesLittle Rock, Arkansas  72205
Hartford HospitalHartford, Connecticut  06102-5037
Eastern Maine Medical CenterBangor, Maine  04401
Franklin Square Hospital CenterBaltimore, Maryland  21237
Baystate Medical CenterSpringfield, Massachusetts  01199
Staten Island University HospitalStaten Island, New York  10305
University of Nebraska Medical CenterOmaha, Nebraska  68198-3330
Kaiser Permanente Medical Center - Santa ClaraSanta Clara, California  95051-5386
University of Oklahoma Health Sciences CenterOklahoma City, Oklahoma  73104
Legacy Emanuel Hospital and Health CenterPortland, Oregon  97227
Iowa Methodist Medical CenterDes Moines, Iowa  50309
Iowa Lutheran HospitalDes Moines, Iowa  50316-2301
Weill Medical College of Cornell UniversityNew York, New York  10021
Southern California Permanente Medical GroupDowney, California  90242
Medical Center of Central GeorgiaMacon, Georgia  31201
Great Falls ClinicGreat Falls, Montana  59405
Thompson Cancer Survival CenterKnoxville, Tennessee  37916
Advocate Christ Medical CenterOak Lawn, Illinois  60453
Lewistown HospitalLewistown, Pennsylvania  17044
Mount Nittany Medical CenterState College, Pennsylvania  16803
Sibley Memorial HospitalWashington, District of Columbia  20016
North Colorado Medical CenterGreeley, Colorado  80631
McKee Medical CenterLoveland, Colorado  80539
Munson Medical CenterTraverse City, Michigan  49684
Bozeman Deaconess HospitalBozeman, Montana  59715
Big Sky OncologyGreat Falls, Montana  59405
Kalispell Medical OncologyKalispell, Montana  59901
Kalispell Regional Medical CenterKalispell, Montana  59901
Avera McKennan Hospital and University Health CenterSioux Falls, South Dakota  57105
Welch Cancer CenterSheridan, Wyoming  82801
Brigham and Women's HospitalBoston, Massachusetts  02115
Elkhart General HospitalElkhart, Indiana  46515
South Bend ClinicSouth Bend, Indiana  46617
Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University Medical CenterColumbus, Ohio  43210-1240
Front Range Cancer SpecialistsFort Collins, Colorado  80528
University Medical Center of Southern NevadaLas Vegas, Nevada  89102
Alta Bates Summit Medical Center - Summit CampusOakland, California  94609
Sutter Solano Medical CenterVallejo, California  94589
Poudre Valley HospitalFort Collins, Colorado  80524
Beebe Medical CenterLewes, Delaware  19958
Memorial HospitalCarthage, Illinois  62321
Mason District HospitalHavana, Illinois  62644
McDonough District HospitalMacomb, Illinois  61455
BroMenn Regional Medical CenterNormal, Illinois  61761
Proctor HospitalPeoria, Illinois  61614
Perry Memorial HospitalPrinceton, Illinois  61356
Bay Regional Medical CenterBay City, Michigan  48708
Mecosta County Medical CenterBig Rapids, Michigan  49307
Community Cancer Center of MonroeMonroe, Michigan  48162
Saint Francis Medical CenterCape Girardeau, Missouri  63701
Great Plains Regional Medical CenterNorth Platte, Nebraska  69101-6598
Grandview HospitalDayton, Ohio  45405
Lima Memorial HospitalLima, Ohio  45804
Mercy Medical CenterSpringfield, Ohio  45504
Mercy Hospital of TiffinTiffin, Ohio  44883
Fulton County Health CenterWauseon, Ohio  43567
Legacy Mount Hood Medical CenterGresham, Oregon  97030
Legacy Meridian Park HospitalTualatin, Oregon  97062
Mountainview MedicalBerlin, Vermont  05602
Exempla Lutheran Medical CenterWheat Ridge, Colorado  80033
Eureka HospitalEureka, Illinois  61530
Mercy HospitalCoon Rapids, Minnesota  55433
Allenmore HospitalTacoma, Washington  98411-0414
Graham Hospital AssociationCanton, Illinois  61520
Holy Family Medical CenterDes Plaines, Illinois  60016
Saint Joseph Medical CenterJoliet, Illinois  60435
Medical Oncology and Hematology AssociatesDes Moines, Iowa  50309
Bixby Medical CenterAdrian, Michigan  49221
Fairview-Southdale HospitalEdina, Minnesota  55435
Abbott-Northwestern HospitalMinneapolis, Minnesota  55407
Regions HospitalSaint Paul, Minnesota  55101
Saint Francis Regional Medical CenterShakopee, Minnesota  55379
Rice Memorial HospitalWillmar, Minnesota  56201
Saint Luke's HospitalMaumee, Ohio  43537
Geisinger Medical GroupState College, Pennsylvania  16801
Highland General HospitalOakland, California  94602
Swedish American HospitalRockford, Illinois  61104
Saint Luke's HospitalChesterfield, Missouri  63017
Miami Valley HospitalDayton, Ohio  45409
Eastern Connecticut Hematology and Oncology AssociatesNorwich, Connecticut  06360
Menorah Medical CenterOverland Park, Kansas  66209
Shawnee Mission Medical CenterShawnee Mission, Kansas  66204
North Kansas City HospitalKansas City, Missouri  64116
Research Medical CenterKansas City, Missouri  64132
Saint Luke's East - Lee's SummitLee's Summit, Missouri  64086
Liberty HospitalLiberty, Missouri  64068
Heartland Regional Medical CenterSaint Joseph, Missouri  64506
Bozeman Deaconess Cancer CenterBozeman, Montana  59715
Northern Montana HospitalHavre, Montana  59501
Wayne HospitalGreenville, Ohio  45331
Fisher-Titus Medical CenterNorwalk, Ohio  44857
Clinton Memorial HospitalWilmington, Ohio  45177
Providence Centralia HospitalCentralia, Washington  98531-9027
Marshfield Clinic Cancer Care at Regional Cancer CenterEau Claire, Wisconsin  54701
Marshfield Clinic - Weston CenterWeston, Wisconsin  54476
Diagnostic and Treatment CenterWeston, Wisconsin  54476
Marshfield Clinic - Wisconsin Rapids CenterWisconsin Rapids, Wisconsin  54494
Rocky Mountain OncologyCasper, Wyoming  82609
Longmont United HospitalLongmont, Colorado  80501
Greene Memorial HospitalXenia, Ohio  45385
Greater Baltimore Medical CenterBaltimore, Maryland  21204
Harold Alfond Center for Cancer CareAugusta, Maine  04330
Union Hospital of Cecil CountyElkton MD, Maryland  21921
Cancer Centers of the Carolinas - Grove CommonsGreenville, South Carolina  29605
Cancer Centers of the Carolinas - SenecaSeneca, South Carolina  29672
Cancer Centers of the Carolinas - SpartanburgSpartanburg, South Carolina  29307
Mayo Clinic in ArizonaScottsdale, Arizona  85259-5404
Washington Hospital CenterWashington, District of Columbia  20010
Memorial Medical CenterSpringfield, Illinois  62781
Phelps County Regional Medical CenterRolla, Missouri  65401
Saint Francis Medical CenterGrand Island, Nebraska  68802
Wellmont Holston Valley Hospital and Medical CenterKingsport, Tennessee  37662
La Grange Memorial HospitalLa Grange, Illinois  60525
Metro Health HospitalGrand Rapids, Michigan  49506
University of North CarolinaChapel Hill, North Carolina  27599
Providence Medical CenterKansas City, Kansas  66112
Lynchburg Hematology-Oncology ClinicLynchburg, Virginia  24501
Northwest Cancer SpecialistsVancouver, Washington  98664
East Bay Radiation Oncology CenterCastro Valley, California  94546
Contra Costa Regional Medical CenterMartinez, California  94553-3156
Memorial Medical CenterModesto, California  95355
Larry G Strieff MD Medical CorporationOakland, California  94609
Hennepin County Medical CenterMinneapolis, Minnesota  
Glens Falls HospitalGlens Falls, New York  12801
Holy Cross HospitalFort Lauderdale, Florida  33308
El Camino HospitalMountain View, California  94040
Cleveland Clinic Florida - WestonWeston, Florida  33331
University of California at San DiegoLa Jolla, California  92093
Wayne State UniversityDetroit, Michigan  48202
Kaiser Permanente Medical CenterVallejo, California  94589
University of Massachusetts Medical SchoolWorcester, Massachusetts  01605
California Pacific Medical CenterSan Francisco, California  94115
Mid Dakota ClinicBismarck, North Dakota  58501
Weiss Memorial HospitalChicago,, Illinois  60640
University Of VermontBurlington,, Vermont  05403
Presbyterian - Saint Lukes Medical Center - Health OneDenver, Colorado  80218
Sacred Heart HospitalPensacola, Florida  32503
Kaiser PermanenteSacramento, California  
University of KentuckyLexington, Kentucky  40536-0098
Montana Cancer Consortium CCOPBillings, Montana  59101
Flower HospitalSylvania, Ohio  43560-2197
Huntsman Cancer Institute/University of UtahSalt Lake City, Utah  84112
Metro-Minnesota CCOPSt. Louis Park, Minnesota  
Cancer Centers of the Carolinas - EasleyEasley, South Carolina  29640
Lakeview HospitalStillwater, Minnesota  55082
Decatur Memorial HospitalDecatur, Illinois  62526
Louisiana State University Health Science CenterNew Orleans, Louisiana  70112
Virginia Commonwealth UniversityRichmond, Virginia  
Kaiser PermanentePortland, Oregon  97227
Montana Cancer SpecialistsMissoula, Montana  59807-7877
Florida HospitalOrlando, Florida  32803
Memorial Health University Medical CenterSavannah, Georgia  31404
University of Chicago Comprehensive Cancer CenterChicago, Illinois  60637-1470
Northern Indiana Cancer Research ConsortiumSouth Bend, Indiana  
Rockwood ClinicSpokane, Washington  99220
Rohnert Park Cancer CenterRohnert Park, California  94928
South Sacramento Cancer CenterSacramento, California  95823
University of CincinnatiCincinnati, Ohio  45267-0502
Penn State Milton S Hershey Medical CenterHershey, Pennsylvania  17033
Southeast Cancer CenterCape Girardeau, Missouri  63703
Butler Memorial HospitalButler, Pennsylvania  16001
Littleton Adventist HospitalLittleton, Colorado  80122
Parker Adventist HospitalParker, Colorado  80138
New Ulm Medical CenterNew Ulm, Minnesota  56073
OSF Saint Francis Medical CenterPeoria, Illinois  61637
Mills - Peninsula HospitalsBurlingame, California  94010
Valley Medical Oncology Consultants-Castro ValleyCastro Valley, California  94546
Valley Medical Oncology Consultants-FremontFremont, California  94538
Kaiser Permanente, FremontFremont, California  94538
Kaiser Permanente, HaywardHayward, California  94545
Bay Area Breast Surgeons IncOakland, California  94609
Bay Area Tumor Institution CCOPOakland, California  94609
Tom K Lee IncOakland, California  94609
Kaiser Permanente-OaklandOakland, California  94611
Kaiser Permanente-Redwood CityRedwood City, California  94063
Kaiser Permanente-RichmondRichmond, California  94801
Kaiser Permanente-RosevilleRoseville, California  95661
Kaiser Permanente-South SacramentoSacramento, California  95823
Kaiser Permanente - SacramentoSacramento, California  95825
Kaiser Permanente-San FranciscoSan Francisco, California  94115
University of California San Francisco Medical Center-Mount ZionSan Francisco, California  94115
Kaiser Permanente-Santa Teresa-San JoseSan Jose, California  95119
Doctors Medical Center- JC Robinson Regional Cancer CenterSan Pablo, California  94806
Kaiser Permanente-San RafaelSan Rafael, California  94903
Kaiser Permanente-Santa RosaSanta Rosa, California  95403
Kaiser Permanente-South San FranciscoSouth San Francisco, California  94080
Kaiser Permanente-StocktonStockton, California  95210
Kaiser Permanente-VallejoVallejo, California  94589
Kaiser Permanente-Walnut CreekWalnut Creek, California  94596
The Medical Center of AuroraAurora, Colorado  80012
Penrose-Saint Francis HealthcareColorado Springs, Colorado  80907
Saint Anthony Central HospitalDenver, Colorado  80204
Exempla Saint Joseph HospitalDenver, Colorado  80218
Colorado Cancer Research Program CCOPDenver, Colorado  80224-2522
Saint Mary's Hospital and Regional Medical CenterGrand Junction, Colorado  81502
Saint Mary Corwin Medical CenterPueblo, Colorado  81004
The Hospital of Central ConnecticutNew Britain, Connecticut  06050
Stamford HospitalStamford, Connecticut  06904
Lombardi Comprehensive Cancer Center at Georgetown UniversityWashington, District of Columbia  20057
M D Anderson Cancer Center- OrlandoOrlando, Florida  32806
Sacred Heart Medical Oncology Group - Davis HighwayPensacola, Florida  32514
Phoebe Putney Memorial HospitalAlbany, Georgia  31703
Saint Luke's Mountain States Tumor InstituteBoise, Idaho  83712
John H Stroger Jr Hospital of Cook CountyChicago, Illinois  60612-3785
Resurrection HealthcareChicago, Illinois  60631
Provena Saint Mary's HospitalKankakee, Illinois  60901
Good Samaritan Regional Medical CenterMt. Vernon, Illinois  62864
Community Cancer Center FoundationNormal, Illinois  61761
Illinois CancerCare-Ottawa ClinicOttawa, Illinois  61350
Ottawa Regional Hospital and Healthcare CenterOttawa, Illinois  61350
Pekin Cancer Treatment CenterPekin, Illinois  61554
Illinois Oncology Research Association CCOPPeoria, Illinois  61615
Illinois CancerCare-PeoriaPeoria, Illinois  61615
Illinois Valley HospitalPeru, Illinois  61354
West Suburban Cancer CenterRiver Forest, Illinois  60305
Reid Hospital and Health Care ServicesRichmond, Indiana  47374
Hematology Oncology Associates-Quad CitiesBettendorf, Iowa  52722
Cedar Rapids Oncology AssociationCedar Rapids, Iowa  52403
Iowa Blood and Cancer Care PLCCedar Rapids, Iowa  52402
Mercy HospitalCedar Rapids, Iowa  52403
Saint Luke's HospitalCedar Rapids, Iowa  52402
Medical Oncology and Hematology Associates-West Des MoinesClive, Iowa  50325
Iowa Oncology Research Association CCOPDes Moines, Iowa  50309
Mercy Medical Center - Des MoinesDes Moines, Iowa  50314
Medical Oncology and Hematology Associates-Des MoinesDes Moines, Iowa  50309
Mercy Medical Center-Sioux CitySioux City, Iowa  51104
Saint Luke's Regional Medical CenterSioux City, Iowa  51104
Stormont-Vail Regional Health CenterTopeka, Kansas  66604
Louisiana State University Sciences Center- MonroeMonroe, Louisiana  71210
Medical Center of LouisianaNew Orleans, Louisiana  70112
Highland ClinicShreveport, Louisiana  71105
Caritas Saint Elizabeth's Medical CenterBrighton, Massachusetts  02135-2997
Berkshire Hematology Oncology PCPittsfield, Massachusetts  01201
Hickman Cancer CenterAdrian, Michigan  49221
Green Bay Oncology - EscanabaEscanaba, Michigan  49431
Grand Rapids Clinical Oncology ProgramGrand Rapids, Michigan  49503
Saint Mary's Health CareGrand Rapids, Michigan  49503
Spectrum Health at Butterworth CampusGrand Rapids, Michigan  49503
Green Bay Oncology - Iron MountainIron Mountain, Michigan  49801
Mercy Memorial HospitalMonroe, Michigan  48162
Mercy Health Partners-Mercy CampusMuskegon, Michigan  49443
Northern Michigan Regional HospitalPetoskey, Michigan  49770
Lakeland HospitalSt. Joseph, Michigan  49085
Medini, Eitan MD (UIA Investigator)Alexandria, Minnesota  56308
Unity HospitalFridley, Minnesota  55432
Saint John's Hospital - HealtheastMaplewood, Minnesota  55109
Minnesota Oncology Hematology PA-MaplewoodMaplewood, Minnesota  55109
Minneapolis Veterans Medical CenterMinneapolis, Minnesota  55417
North Memorial Medical Health CenterRobbinsdale, Minnesota  55422
Saint Cloud HospitalSaint Cloud, Minnesota  56303
Park Nicollet Clinic - Saint Louis ParkSaint Louis Park, Minnesota  55416
Minnesota Oncology and Hematology PA-WoodburyWoodbury, Minnesota  55125
Saint John's Regional Medical CenterJoplin, Missouri  64804
Freeman Health SystemJoplin, Missouri  64804
Saint Luke's Cancer InstituteKansas City, Missouri  64111
Saint Luke's Hospital of Kansas CityKansas City, Missouri  64111
Saint Joseph Health CenterKansas City, Missouri  64114
Liberty Radiation Oncology ClinicKansas City, Missouri  64116
Truman Medical CenterKansas City, Missouri  64108
Saint Louis-Cape Girardeau CCOPSaint Louis, Missouri  63141
Missouri Baptist Medical CenterSaint Louis, Missouri  63131
Saint John's Mercy Medical CenterSaint Louis, Missouri  63141
Ozark Health Ventures LLC dba Cancer Research for The Ozarks SpringfieldSpringfield, Missouri  65802
Saint John's HospitalSpringfield, Missouri  65804
Cox Medical CenterSpringfield, Missouri  65807
Hematology-Oncology Centers of the Northern Rockies PCBillings, Montana  59101
Saint Vincent HealthcareBillings, Montana  59101
Billings ClinicBillings, Montana  59107-7000
Saint James Community Hospital and Cancer Treatment CenterButte, Montana  59701
Benefis Healthcare- Sletten Cancer InstituteGreat Falls, Montana  59405
Saint Peter's Community HospitalHelena, Montana  59601
Glacier Oncology PLLCKalispell, Montana  59901
Saint Patrick Hospital - Community HospitalMissoula, Montana  59802
Good Samaritan HospitalKearney, Nebraska  68847
Nevada Cancer Research Foundation CCOPLas Vegas, Nevada  89106
Cooper Hospital University Medical CenterCamden, New Jersey  08103
Fox Chase Cancer Center at Virtua Memorial Hospital of Burlington CountyMount Holly, New Jersey  08060
Virtua West Jersey Hospital VoorheesVoorhees, New Jersey  08043
Veterans Affairs Western New York Health Care System-BuffaloBuffalo, New York  14215
Orange Regional Medical CenterMiddletown, New York  10940
State University of New York Upstate Medical UniversitySyracuse, New York  13210
Mission Hospitals IncAsheville, North Carolina  28801
Wayne Memorial HospitalGoldsboro, North Carolina  27534
Margaret R Pardee Memorial HospitalHendersonville, North Carolina  28791
Kinston Medical Specialists PAKinston, North Carolina  28501
Marion L Shepard Cancer CenterWashington, North Carolina  27889
Saint Alexius Medical CenterBismarck, North Dakota  58501
Summa Barberton HospitalBarberton, Ohio  44203
Good Samaritan Hospital - DaytonDayton, Ohio  45406
Dayton CCOPDayton, Ohio  45429
Samaritan North Health CenterDayton, Ohio  45415
Hematology Oncology Center IncorporatedElyria, Ohio  44035
Blanchard Valley HospitalFindlay, Ohio  45840
Atrium Medical Center-Middletown Regional HospitalFranklin, Ohio  45005-1066
Kettering Medical CenterKettering, Ohio  45429
Saint Rita's Medical CenterLima, Ohio  45801
Toledo Radiation Oncology at Northwest Ohio Onocolgy CenterMaumee, Ohio  43537
Saint Charles HospitalOregon, Ohio  43616
North Coast Cancer CareSandusky, Ohio  44870
Toledo Community Hospital Oncology Program CCOPToledo, Ohio  43617
Mercy Cancer Center at Saint Anne Mercy HospitalToledo, Ohio  43623
University of ToledoToledo, Ohio  43614
Saint Vincent Mercy Medical CenterToledo, Ohio  43608
Upper Valley Medical CenterTroy, Ohio  45373
Wright-Patterson Medical CenterWright-Patterson Afb, Ohio  45433-5529
Legacy Good Samaritan Hospital and Medical CenterPortland, Oregon  97210
Northwest Cancer Specialists-Rose Quarter Cancer CenterPortland, Oregon  97227
Ephrata Cancer CenterEphrata, Pennsylvania  17522
Riddle HospitalMedia, Pennsylvania  19063
Hematology and Oncology Associates of North East PennsylvaniaScranton, Pennsylvania  18508
Associates In Hematology Oncology PC-UplandUpland, Pennsylvania  19013
Geisinger Wyoming ValleyWilkes-Barre, Pennsylvania  18711
Greenville Memorial HospitalGreenville, South Carolina  29605
Fredericksburg Oncology IncFredericksburg, Virginia  22401
Southwest VA Regional Cancer CenterNorton, Virginia  24273
Saint Francis HospitalFederal Way, Washington  98003
Providence - Saint Peter HospitalOlympia, Washington  98506-5166
Good Samaritan Community HospitalPuyallup, Washington  98372
Northwest CCOPTacoma, Washington  98405
Multicare Health SystemTacoma, Washington  98415
Saint Clare HospitalTacoma, Washington  98499
Saint Joseph Medical CenterTacoma, Washington  98405
Langlade Hospital and Cancer CenterAntigo, Wisconsin  54409
Saint Vincent HospitalGreen Bay, Wisconsin  54301
Green Bay Oncology Limited at Saint Mary's HospitalGreen Bay, Wisconsin  54303
Saint Mary's HospitalGreen Bay, Wisconsin  54303
Green Bay Oncology at Saint Vincent HospitalGreen Bay, Wisconsin  54301-3526
Bay Area Medical CenterMarinette, Wisconsin  54143
Marshfield Clinic-Minocqua CenterMinocqua, Wisconsin  54548
Green Bay Oncology - Oconto FallsOconto Falls, Wisconsin  54154
Marshfield Clinic at James Beck Cancer CenterRhinelander, Wisconsin  54501
Marshfield Clinic-Rice Lake CenterRice Lake, Wisconsin  54868
Green Bay Oncology - Sturgeon BaySturgeon Bay, Wisconsin  54235
Aspirus Regional Cancer CenterWausau, Wisconsin  54401
Jupiter Medical CenterJupiter, Florida  33458
University of IllinoisChicago, Illinois  60612
Lahey Clinic Medical CenterBurlington, Massachusetts  01805
Elkhart ClinicElkhart, Indiana  46515
Mount Sinai Medical Center CCOPMiami Beach, Florida  33140
Illinois CancerCare-BloomingtonBloomington%, Illinois  61701
Illinois CancerCare-CantonCanton, Illinois  61520
Illinois CancerCare-CarthageCarthage, Illinois  62321
Jesse Brown Veterans Affairs Medical CenterChicago, Illinois  60612
Illinois CancerCare-EurekaEureka, Illinois  61530
Illinois CancerCare-HavanaHavana, Illinois  62644
Illinois CancerCare-Kewanee ClinicKewanee, Illinois  61443
Illinois CancerCare-MacombMacomb, Illinois  61455
Illinois CancerCare-MonmouthMonmouth, Illinois  61462
Illinois CancerCare-Community Cancer CenterNormal, Illinois  61761
Illinois CancerCare-PekinPekin, Illinois  61603
Illinois CancerCare-PeruPeru, Illinois  61354
Illinois CancerCare-PrincetonPrinceton, Illinois  61356
Illinois CancerCare-Spring ValleySpring Valley, Illinois  61362
Michiana Hematology Oncology PC-ElkhartElkhart, Indiana  46514
Michiana Hematology Oncology PC-PlymouthPlymouth, Indiana  46563
Michiana Hematology Oncology PC-South BendSouth Bend, Indiana  46601
Michiana Hematology Oncology-PC WestvilleWestville, Indiana  46391
Michiana Hematology Oncology PC-NilesNiles, Michigan  49120
Central Care Cancer Center-Carrie J Babb Cancer CenterBolivar, Missouri  65613
Skaggs Cancer CenterBranson, Missouri  65616
University of Missouri - Ellis FischelColumbia, Missouri  65203
North Coast Cancer Care-ClydeClyde, Ohio  43410
Community Health Partners Regional Medical CenterElyria, Ohio  44035
Roper HospitalCharleston, South Carolina  29401
Cancer Centers of the Carolinas - FarisGreenville, South Carolina  29605
Cancer Centers of the Carolinas-Greer Medical OncologyGreer, South Carolina  29650
University of Tennessee - KnoxvilleKnoxville, Tennessee  37920
West Virginia University CharlestonCharleston, West Virginia  25304
Marshfield Clinic-Chippewa CenterChippewa Falls, Wisconsin  54729
Holy Family Memorial HospitalManitowoc, Wisconsin  54221
Marshfield Clinic Cancer Care at Saint Michael's HospitalStevens Point, Wisconsin  54481
Riverview HospitalWisconsin Rapids, Wisconsin  54494
Cancer Centers of Southwest Oklahoma ResearchLawton, Oklahoma  
Saint Luke's Mountain States Tumor Institute - FruitlandFruitland, Idaho  83619
Kaiser Anaheim Medical CenterAnaheim, California  92807
Kaiser Permanente-Deer Valley Medical CenterAntioch, California  94531
Kaiser Permanente Medical Group - Baldwin ParkBaldwin Park, California  91706
Kaiser Foundation HospitalBellflower, California  90706
Kaiser Permanente HospitalFontana, California  92335
Kaiser Permanente - Harbor CityHarbor City, California  90710
Kaiser Permanente-West Los AngelesLos Angeles, California  90034
Epic Care-OaklandOakland, California  94612
Kaiser Permanente Oakland-BroadwayOakland, California  94611
Kaiser Permanente - Panorama CityPanorama City, California  91402
Palchak David MDPismo Beach, California  93449
Kaiser Permanente-Rancho Cordova Cancer CenterRancho Cardova, California  95670
The Permanente Medical Group-Roseville Radiation OncologyRoseville, California  95678
Kaiser Permanente at San DiegoSan Diego, California  92120
Kaiser Permanente Health CareSan Marcos, California  92069
Kaiser Permanente Cancer Treatment CenterSouth San Francisco, California  94080
Kaiser Permanente Medical Center-VacavilleVacaville, California  95688
Kaiser Permanente-Rock CreekLafayette, Colorado  80026
Kaiser Permanente Moanalua Medical CenterHonolulu, Hawaii  96819
Saint Luke's Mountain States Tumor Institute - MeridianMeridian, Idaho  83642
Saint Luke's Mountain States Tumor Institute - NampaNampa, Idaho  83686
Saint Luke's South HospitalOverland Park, Kansas  66213
Kansas City CCOPPrairie Village, Kansas  66208
Singh and Arora Hematology Oncology PCFlint, Michigan  48532
Great Lakes Cancer Institute-Lapeer CampusLapeer, Michigan  48446
Mount Clemens Regional Medical CenterMount Clemens, Michigan  48043
Spectrum Health Reed City HospitalReed City, Michigan  49677
Capital Region Medical Center-Goldschmidt Cancer CenterJefferson City, Missouri  65109
Heartland Hematology and Oncology Associates IncorporatedKansas City, Missouri  64118
Saint John's Clinic-Rolla-Cancer and HematologyRolla, Missouri  65401
Saint Joseph Oncology IncSaint Joseph, Missouri  64507
Comprehensive Cancer Care PCSaint Louis, Missouri  63141
Cancer Care Associates-MercyOklahoma City, Oklahoma  73120
Mid-Columbia Medical CenterThe Dalles, Oregon  97058
Susquehanna Cancer CenterWilliamsport, Pennsylvania  17701
Legacy Salmon Creek HospitalVancouver, Washington  98686
Gundersen LutheranLa Crosse, Wisconsin  54601
Saint Nicholas HospitalMadison, Wisconsin  53715
San Francisco General HospitalSan Francisco, California  94110
Kaiser Permanente-FranklinDenver, Colorado  80205
Siouxland Hematology Oncology AssociatesSioux City, Iowa  51101
Walter Reed National Military Medical CenterBethesda, Maryland  20889
VA Medical Center - University of IowaIowa City, Iowa  52246
Methodist West HospitalWest Des Moines, Iowa  50266-7700
Radiation Oncology Associates PCFort Wayne, Indiana  46804
Alta Bates Summit Medical Center-Herrick CampusBerkeley, California  94704
Carle Foundation - Carle Cancer CenterUrbana, Illinois  61801
Michiana Hematology Oncology PC-MishawakaMishawaka, Indiana  46545-1470
Oncology Associates at Mercy Medical CenterCedar Rapids, Iowa  52403
Marie Yeager Cancer CenterSaint Joseph, Michigan  49085
Hematology Oncology Associates of Central New York PCEast Syracuse, New York  13057
Summa Akron City HospitalAkron, Ohio  44304
Franciscan St. Francis HealthIndianapolis, Indiana  46237
The Toledo Hospital/Toledo Children's HospitalToledo, Ohio  43606
Sanford Bismarck Medical CenterBismarck, North Dakota  58501
Toledo Clinic Cancer Centers-OregonOregon, Ohio  43616
Geisinger Medical Center-Cancer Center HazeltonHazleton, Pennsylvania  18201
Community Howard Regional HealthKokomo, Indiana  46904
Indiana University Health La Porte HospitalLa Porte, Indiana  46350
Saint Joseph Regional Medical Center-MishawakaMishawaka, Indiana  46545-1470
Aurora Cancer Care-Milwaukee WestWauwatosa, Wisconsin  53226
Christiana Care Health System-Christiana HospitalNewark, Delaware  19718
Bronson Battle CreekBattle Creek, Michigan  49017
Saint Louis Cancer and Breast Institute-South CitySaint Louis, Missouri  63109
Toledo Clinic Cancer Centers-Bowling GreenBowling Green, Ohio  43402
Toledo Clinic Cancer Centers-MaumeeMaumee, Ohio  43537-1839
Toledo Clinic Cancer Centers-ToledoToledo, Ohio  43623
Guthrie Clinic-Robert Packer HospitalSayre, Pennsylvania  18840
Self Regional HealthcareGreenwood, South Carolina  29646
Sutter Pacific Medical FoundationSanta Rosa, California  95403
NEA Baptist Clinic-MatthewsJonesboro, Arkansas  72401
Saint Luke's Mountain States Tumor Institute-Twin FallsTwin Falls, Idaho  83301
Cancer Care Associates-NormanNorman, Oklahoma  73071
Mercy Physicians of Oklahoma-LakesideOklahoma City, Oklahoma  73120
Mercy Cancer Center-West LakesClive, Iowa  50325
Mercy Medical Center-West LakesWest Des Moines, Iowa  50266
White River Junction Veteran Administration Medical CenterWhite River Junction, Vermont  05009