Does Smoking Status After Being Diagnosed With Lung Cancer Influence Outcome? An Observational Cohort Study Alongside a Randomised Trial of Different Smoking Cessation Interventions.
Smoking causes around 85% of lung cancer. Continued smoking after diagnosis probably worsens
survival and increases treatment complications but prospective well-designed studies are
lacking.
This project consists of two simultaneous studies:
1. An observational cohort study recording outcomes in smokers, never-smokers, and
ex-smokers, using exhaled carbon monoxide to validate smoking status when they attend
for further lung cancer clinics.
2. A pilot controlled trial (RCT) where proven (eCO>10 ppm or self reported) smokers
receiving a diagnosis of lung cancer will be randomised to receive either standardized
physician-initiated advice to stop smoking or a referral to our specialist
hospital-based smoking cessation service.
This project is unique, as every patient with a clinical diagnosis of lung cancer will have
their smoking status biologically validated by a quick and easy test, and those enrolled in
the smoking cessation trial will also complete a generic quality of life questionnaire at
regular intervals. These appointments will coincide with other hospital appointments
wherever possible, and survival status will reported up to 24 months after enrolment.
Interventional
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Median and 2-year survival rates in confirmed smokers versus non- smokers newly diagnosed with lung cancer.
24 months
No
Keir E Lewis, MD
Principal Investigator
Hywel Dda
United Kingdom: National Health Service
09/WMW01/28
NCT01192256
March 2010
March 2015
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