Does Smoking Status After Being Diagnosed With Lung Cancer Influence Outcome? An Observational Cohort Study Alongside a Randomised Trial of Different Smoking Cessation Interventions.
Smoking causes around 85% of lung cancer. Continued smoking after diagnosis probably worsens
survival and increases treatment complications but prospective well-designed studies are
This project consists of two simultaneous studies:
1. An observational cohort study recording outcomes in smokers, never-smokers, and
ex-smokers, using exhaled carbon monoxide to validate smoking status when they attend
for further lung cancer clinics.
2. A pilot controlled trial (RCT) where proven (eCO>10 ppm or self reported) smokers
receiving a diagnosis of lung cancer will be randomised to receive either standardized
physician-initiated advice to stop smoking or a referral to our specialist
hospital-based smoking cessation service.
This project is unique, as every patient with a clinical diagnosis of lung cancer will have
their smoking status biologically validated by a quick and easy test, and those enrolled in
the smoking cessation trial will also complete a generic quality of life questionnaire at
regular intervals. These appointments will coincide with other hospital appointments
wherever possible, and survival status will reported up to 24 months after enrolment.
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Median and 2-year survival rates in confirmed smokers versus non- smokers newly diagnosed with lung cancer.
Keir E Lewis, MD
United Kingdom: National Health Service