Long Chain (LC) n-3 Polyunsaturated Fatty Acids (PUFA) Supplementation in Young Women With Polycystic Ovary Syndrome (PCOS): A Cross-over, Placebo Controlled Dietary Intervention Study
Polycystic ovary syndrome (PCOS) is a chronic condition affecting young women of
reproductive age. Long-term, safe and efficacious treatments are needed for women with this
condition, and dietary therapy may have an important role in its treatment. LC n-3 PUFA have
been shown to be potent biological regulators, involved in the amelioration of many of the
adverse metabolic risk factors which are often present in women with PCOS. The aim of this
study was to explore the impact of LC n-3 PUFA on fasting and post-prandial lipid
metabolism, as well as on the hormonal profile of women with PCOS.
Interventional
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
Fasting lipid metabolism
Following supplementation with LCn-3 PUFA or placebo for 6 weeks
No
James Gibney, Dr
Principal Investigator
The Adelaide and Meath Hospital, Incorporating the National Children's Hospital
Ireland: Research Ethics Committee
DDC-UCD-PCOS
NCT01189669
September 2007
July 2008
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