Inclusion Criteria:

- Histologically confirmed squamous cell carcinoma of the head and neck incurable
by surgery or radiation

- Patients must have measurable disease, defined as at least on e lesion that can be
accurately measured in the one dimension (longer diameter to be recorded) as greater
then or equal to 20mm with conventional techniques or as greater than or equal to
10mm with computed tomograpy (CT) scan.

Therapeutic history that includes the Following:

- No prior EGFR-based therapy for recurrent disease

- No chemotherapy or irradiation with the 28-day period preceding entry to the study

- Eastern Cooperative Oncology Group (ECOG)performance Status 0-2 (kamofsky >59%)

Patients must have normal organ and marrow function as defined below:

- leukocytes >3,000ml

- absolute neutrophil count 1,500/ml

- platelets 100,000/ml

- total bilirubin within normal institutional limits

- AST(SGOT)ALT(SGPT) <2.5 X institutional upper limits of normal

- Creatinine <1.5

Exclusion Criteria:

- Other coexisting malignancies or malignancies diagnosed within the last 5 years with
the exception of basal cell carcinoma or cervical in situ.

- Concomitant use of phenytoin, carbamazepine, barbiturates, rifampicin, phenobarbital,
ketoconazole, erythromycin, clarithromycin, atorvastatin, cimetidine, ametidine,
amitriptyline, imipramine, verpamil, tamoxifen, chlorpromazine, amiodorone,
chloroquine, St. John's Wort

- Any unresolved chronic toxicity greater than CTC grade 2 from previous anticancer
therapy

- Incomplete healing from previous oncologic or other major surgery Patients may not be
receiving any other investigational agents

- History of allergic reactions attributed to compound of similar chemical or biologic
composition to ZD 1839

- Uncontrolled intercurrent illness

- Pregnancy or breast feeding (women of child -bearing potential