Palliative Stenting With or Without Radiotherapy for Inoperable Oesophageal Carcinoma: a Randomised Trial
A majority of patients with oesophageal cancer present with inoperable disease and require
rapid and long lasting palliation of dysphagia.
STUDY AIM: To compare dysphagia relief in patients treated with oesophageal stenting and
external beam radiotherapy (EBRT), versus oesophageal stenting alone and to assess overall
survival, treatment related complications, and quality of life in the two groups.
PATIENTS AND METHODS: Patients with inoperable oesophageal cancer with high grade dysphagia
to be randomised to receive oesophageal stenting alone (Group I), versus a combination of
stenting followed by EBRT (Group II). Dysphagia relief, treatment related complications,
overall survival, and quality of life to be assessed in the two groups.
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Supportive Care
Relief of dysphagia
Relief of dysphagia will be assessed by stratifying the ability to swallow into the following grades. Grade 1: Difficulty in swallowing solid food Grade 2: Difficulty in swallowing semisolid food Grade 3: Difficulty in swallowing liquids Grade 4: Difficulty in swallowing even saliva The dysphagia scores will be assessed 1 week after intervention (stenting and radiotherapy)in the two groups
1 week after intervention
Tushar K Chattopadhyay, MS
Head, Dept. G.I Surgery, All India Institute of Medical Sciences, New Delhi
India: Indian Council of Medical Research