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Validation of AML Proteomic Signature Associated With Clinical Response to Ara-C Based Induction Therapy in Patients 60 Years of Age or Older Using Samples From ECOG Studies 3999, 3993 and 1490


N/A
60 Years
N/A
Not Enrolling
Both
Leukemia

Thank you

Trial Information

Validation of AML Proteomic Signature Associated With Clinical Response to Ara-C Based Induction Therapy in Patients 60 Years of Age or Older Using Samples From ECOG Studies 3999, 3993 and 1490


OBJECTIVES:

Primary

- To validate a pre-specified proteomic classifier to predict the likelihood of complete
response (CR) to cytarabine-based induction chemotherapy in older patients with non-M3
acute myeloid leukemia.

Secondary

- To identify signaling nodes associated with risk of relapse among these patients who
achieve a CR to induction chemotherapy.

OUTLINE: This is a multicenter study.

Previously collected bone marrow and peripheral blood samples are analyzed to validate the
association of a pre-specified proteomic signature with clinical response via flow
cytometry.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Treated on EST-1490, E-3993, or ECOG-E3999

- Bone marrow and peripheral blood samples collected at diagnosis and before induction
chemotherapy available

- No M3 disease

PATIENT CHARACTERISTICS:

- Not specified

PRIOR CONCURRENT THERAPY:

- See Disease Characteristics

Type of Study:

Observational

Study Design:

N/A

Outcome Measure:

Proportion of patients achieving a complete response to induction chemotherapy

Safety Issue:

No

Principal Investigator

Elisabeth Paietta, PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Our Lady of Mercy Medical Center Comprehensive Cancer Center

Authority:

Unspecified

Study ID:

CDR0000681533

NCT ID:

NCT01169363

Start Date:

October 2009

Completion Date:

Related Keywords:

  • Leukemia
  • adult acute myeloid leukemia in remission
  • recurrent adult acute myeloid leukemia
  • adult erythroleukemia (M6a)
  • adult pure erythroid leukemia (M6b)
  • adult acute megakaryoblastic leukemia (M7)
  • adult acute minimally differentiated myeloid leukemia (M0)
  • adult acute monoblastic leukemia (M5a)
  • adult acute monocytic leukemia (M5b)
  • adult acute myeloblastic leukemia with maturation (M2)
  • adult acute myeloblastic leukemia without maturation (M1)
  • adult acute myelomonocytic leukemia (M4)
  • adult acute myeloid leukemia with 11q23 (MLL) abnormalities
  • adult acute myeloid leukemia with del(5q)
  • adult acute myeloid leukemia with inv(16)(p13;q22)
  • adult acute myeloid leukemia with t(16;16)(p13;q22)
  • adult acute myeloid leukemia with t(8;21)(q22;q22)
  • Leukemia
  • Leukemia, Myeloid, Acute
  • Leukemia, Myeloid

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