Inclusion Criteria:

- Aged between 18 and 70 years.

- Radiological suspicion of newly- or recurrent malignant glioma (WHO grades III/IV).

- Indication for surgical tumor resection.

- Karnofsky Performance Score of 60 or higher.

- Provides signed informed consent prior to any study procedures.

- Comply with visit schedule and other rules for patients in study protocol.

Exclusion Criteria:

- Porphyria, hypersensitivity to porphyrins.

- Renal insufficiency: Creatinine 2.0 mg/dL or higher

- Hepatic insufficiency: ALT 100 IU/L or higher, AST 100 IU/L or higher, γ-GTP 100 IU/L
or higher or total bilirubin 3 mg/dL or higher

- Chemotherapy or other treatment for other malignant tumors

- Females who are pregnant or potentially childbearing or are breastfeeding

- Participation in other clinical trial in the previous 1 month

- Ineligible patient based on the judgement of the investigator.