Inclusion Criteria:

1. Histological/cytological diagnosis of solid tumors in which treatment with
Carboplatin and Paclitaxel is indicated, e.g. NSCLC, GY tumors, prostate cancer,
unknown primary

2. Progressive disease (also in terms of tumor markers only, like CA 125 for ovary and
PSA for prostate).

3. Age 18-75 years

4. Prior chemotherapy of ≤ 1 line for advanced disease

5. ECOG Performance Status < 2

6. Life expectancy of at least 3 months

7. The patient must be able to read, understand and provide written evidence of informed
consent

8. Female patients may not be pregnant or lactating and must be willing to practice
contraception. The effects of LBH589 on the developing human fetus are unknown. For
this reason, women of childbearing potential must agree to use adequate contraception
(hormonal or barrier method of birth control or abstinence) prior to study entry and
for the duration of study participation.

9. Male patients that are not surgically sterile must be practicing a medically
acceptable contraceptive regimen while on study treatment

10. Adequate organ function as defined by the following:

- ANC > 1500/µL

- Platelets ≥ 100,000/µL

- Haemoglobin ≥ 10 g/dl

- Serum creatinine ≤ 1.5 x ULN or 24-hour creatinine clearance ≥ 60 ml/min

- Magnesium, potassium and phosphorus ≥ the lower limit of normal or correctable
with supplements

- Aspartate aminotransferase (AST/SGOT) and alanine aminotransferase (ALT/SGPT) ≤
2.5 x ULN or ≤ 5.0 x ULN if hepatic involvement is present

- Serum bilirubin ≤ 1.5 x ULN

- Alkaline phosphatase (ALP) ≤ 2.5 x ULN or ALP > 2.5 x UNL with liver fraction ≤
2.5 x ULN

Exclusion Criteria:

1. Other chemotherapy treatment < 4 weeks prior to enrolment

2. Hypersensitivity or allergic reactions to platinum compounds or Carboplatin®;
hypersensitivity or allergic reactions to Paclitaxel

3. Radiotherapy involving > 30% of the active bone marrow

4. Radiotherapy < 4 weeks prior to enrolment

5. Pre-existing peripheral neuropathy ≥ grade 2

6. Pre-existing CTCAE hearing loss or tinnitus ≥ grade 2

7. Symptomatic pleural effusion

8. Clinically significant third space fluid accumulation (e.g. ascites,..)

9. Symptomatic brain metastasis or meningeal tumors

10. Patients who have not recovered (> grade 1) from the following toxicities of previous
regimens before enrolment: fatigue, mucositis, nausea/vomiting, diarrhea

11. Concurrent enrolment, or previous enrolment within 30 days prior to registration in
another investigational device or drug trial(s) or is receiving other investigational
agent(s)

12. Human immunodeficiency virus (HIV) infection

13. History of bone marrow or major organ transplant

14. Prior high dose treatment with PBSC support

15. Impaired cardiac function, including any one of the followings:

- Complete Left Bundle Branch Block or obligate use of a cardiac pacemaker or
congenital long QT syndrome or history or presence of atrial or ventricular
tachyarrhythmias or clinically significant resting bradycardia (< 50 beats per
minute) or QTcF > 480 msec on screening ECG or Right Bundle Branch block + left
anterior hemiblock (bifascicular block)

- Angina pectoris or acute MI ≤ 3 months prior to starting study drug

- Other clinically significant heart disease (e.g. congestive heart failure,
uncontrolled hypertension, history of labile hypertension, or history of poor
compliance with an antihypertensive regimen)

16. Impairment of gastrointestinal (GI) function or GI disease that may significantly
alter the absorption of oral LBH589 (e.g., ulcerative diseases, uncontrolled nausea,
vomiting, malabsorption syndrome, or small bowel resection)

17. Acute or chronic liver or renal disease

18. Other concurrent severe and/or uncontrolled medical conditions (e.g., uncontrolled
diabetes, active or uncontrolled infection, chronic obstructive or chronic
restrictive pulmonary disease) that could cause unacceptable safety risks or
compromise compliance with the protocol

19. Concomitant use of CYP3A4/5 inhibitors or inducers where the treatment can not be
discontinued or switched to a different medication prior to starting study drug
(medications listed in Appendix 3). The medications listed in Appendix 3 have a
relative risk of prolonging the QT interval or inducing Torsades de Pointes, but do
not represent an exclusion criteria

20. Treatment with any hematopoietic colony-stimulating growth factors (e.g., G-CSF,
GMCSF) ≤ 2 weeks prior to starting study drug.

21. Treatment with therapeutic doses of sodium warfarin (Coumarin ). Low doses of
Coumarin (e.g., ≤ 2 mg/day) for line patency is allowable

22. Patients who have received biologic therapy (excluding antiangiogenics) or
immunotherapy ≤ 2 weeks prior to starting study treatment or who have not recovered
from side effects of such therapy

23. Patients who have undergone major surgery ≤ 2 weeks prior to starting study drug or
who have not recovered from side effects of such therapy

24. Unable or unwilling to comply with all study procedures

25. Current history of alcohol or drug abuse