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Improved Breast Dynamic Contrast Enhanced-magnetic Resonance Imaging (DCE-MRI) With Sweep Imaging With Fourier Transform (SWIFT)

18 Years
80 Years
Open (Enrolling)
Breast Cancer

Thank you

Trial Information

Improved Breast Dynamic Contrast Enhanced-magnetic Resonance Imaging (DCE-MRI) With Sweep Imaging With Fourier Transform (SWIFT)

Patients will be asked to come to the Center for Magnetic Resonance Research (CMRR) at the
University of Minnesota. Researchers will interview the patient and describe procedures and
risks. An intravenous (IV) line will be placed in an upper extremity for infusing magnetic
resonance imaging (MRI) contrast dye. Baseline MRI scans will be done. These MRI
measurements will be compared with clinical, radiological and pathological findings (the
gold standard).

Follow-up contact will occur within one year after the MRI to determine whether a pathology
report is available.

Inclusion Criteria:

- Women with a clinically or mammographically identified suspicious breast mass that is
likely to be biopsied or surgically removed.

Exclusion Criteria:

- Pregnancy

- Ferromagnetic implants

- History of shotgun wounds and shrapnel

- Obesity (>250 pounds)

- Cardiac pacemaker

- Incompatible implanted medical device

- Severe claustrophobia

- Major surgeries with potential of ferromagnetic implants

- Severe asthma and allergies

- i-STAT system, a handheld blood analyzer (I-STAT) creatinine test, estimated
glomerular filtration rate (GFR) <30

- Metallic object (greater than 2 cm in length) in the breast

- Metallic ink tatoo within 20 cm of the breast (approximately 8 inches)

Type of Study:


Study Design:

Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Diagnostic

Outcome Measure:

Optimize Sweep Imaging with Fourier Transform magnetic resonance imaging (SWIFT MRI) for Breast

Outcome Description:

Optimization and validation of the basic SWIFT sequence - develop guidelines for minimal clinical implementation.

Outcome Time Frame:

Baseline (7/2010 - 12/2010)

Safety Issue:


Principal Investigator

Curtis Corum, Ph.D.

Investigator Role:

Principal Investigator

Investigator Affiliation:

Masonic Cancer Center, University of Minnesota


United States: Institutional Review Board

Study ID:




Start Date:

August 2009

Completion Date:

March 2014

Related Keywords:

  • Breast Cancer
  • Breast Neoplasms



Center for Magnetic Resonance Research Minneapolis, Minnesota  55455