Effects of Physical Activity on Insulin Resistance and Adiposity in Polycystic Ovary Syndrome "Poly"
Young, overweight/obese women with PCOS along with age and BMI-matched healthy controls
without PCOS will be enrolled in this study. Participants will have assessments of body
composition (by DEXA), visceral and ectopic fat (by MR), ovarian parameters (follicle size
and number, by MRI) insulin sensitivity (by euglycemic hyperinsulinemic clamp), interstitial
lipolysis (by microdialysis), whole body lipolysis and glycolysis (by stable isotopes),
aerobic fitness (by VO2max test) and a fat biopsy performed across two clinic visits (1
outpatient visit, and 1 overnight stay). Participants in the control group will undergo
these assessments once only, whereas participants in the PCOS Group will have these
assessments twice, once at baseline and once following a 16 week supervised aerobic exercise
program. Throughout the exercise program body weight will be measured weekly and menstrual
cycle frequency will be documented on a calendar. Additionally, vital signs, weight, waist
and hip circumferences will be measured and a fasting blood sample collected every 4 weeks.
Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention
Change in Insulin sensitivity as measured by the euglycemic hyperinsulinemic clamp
16-weeks of aerobic exercise training on: peripheral insulin sensitivity (euglycemic-hyperinsulinemic clamp) and catecholamines (microdialysis) during a euglycemic-hyperinsulinemic clamp.
Baseline and 16-weeks
Leanne Readman, PhD
Pennington Biomedical Research Center
United States: Institutional Review Board
|Pennington Biomedical Research Center||Baton Rouge, Louisiana 70808|