Inclusion Criteria:

1. Age 18-70 years

2. MM patients in first or second complete or partial remission

3. ECOG performance status of 0 or 1

4. Up to 3 prior treatment regimens

5. Meet all eligibility requirements for autologous transplant

6. Adequate marrow function defined as WBC >3,000; ANC >1,500/mm3 ; Platelets
>75,000/mm3

7. Adequate renal function defined as creatinine clearance > 30 mL/min by
Cockcroft-Gault

8. Adequate liver function defined as AST/ALT/Bilirubin < 2 times upper limit of normal

9. Able to provide informed consent

10. Women not pregnant and agree to use contraception

Exclusion Criteria:

1. High risk co-morbidities for acute treatment complications (e.g., symptomatic
coronary artery disease)

2. Brain metastases or carcinomatous meningitis

3. Previous treatment with high dose chemotherapy and autologous transplant.

4. Previous attempt to collect B-HPCs following mobilization with growth factors alone,
growth factors and chemotherapy, or plerixafor and growth factors.

5. Acute infection or unexplained fever >38°C

6. Weight > 175% of ideal body weight as defined by the Devine equation.

7. Experimental therapy within 4 weeks

8. Cytokine administration in the previous 14 days