Inclusion Criteria:

- Epidermal carcinoma proven histologically of the sphere ORL (all locations except
nasopharynx).

- Patients with tumours of the oral cavity, the oropharynx, the hypopharynx and the
larynx treated initially by surgery and eligible for post-operative radio-
chemotherapy concomitantly.

NB. The patients with tumours of the larynx or hypopharynx are eligible if the
radiotherapy to the oropharyngeal mucosa will be at least 54 Gy and the mucositis can be
visualised without the use of instruments.

- Radio-chemotherapy to be given postoperatively.

- Maximum delay of 8 weeks between the operative date and the planned starting date of
radio-chemotherapy.

- Performance status (grade OMS): 0, 1, 2

- Nutritional Risk Index ≥ 83.5

- No mucositis.

- Age: 18-75 years

- Life expectancy ≥ 3 months.

- Informed consent obtained from the patient.

- Affiliation with a social security system.

Exclusion Criteria:

- Tumour of nasopharynx

- Mucositis

- Severe sepsis

- Treatment by immunomodulators in the month preceding inclusion

- ATCD allergy to the components of Oral Impact.

- Parenteral nutrition at inclusion

- Usual contraindications to concomitant radio-chemotherapy

- Patient already included in another therapeutic trial involving an experimental
molecule

- Female pregnant or susceptible to being pregnant, or breast-feeding. Patient not
using appropriate contraceptive measures during the treatment

- Persons deprived of liberty or under guardianship

- Patients unable to commit to the trial schedule for geographical, social or
psychological reasons.