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Identification of de Novo Fanconi Anemia Patients Using FANCD2 Western Blots


N/A
N/A
21 Years
Open (Enrolling)
Both
Fanconi Anemia, Leukemia, Myelodysplastic Syndromes

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Trial Information

Identification of de Novo Fanconi Anemia Patients Using FANCD2 Western Blots


OBJECTIVES:

- Identify children with newly diagnosed acute myeloid leukemia (AML) treated on COG-2961
and COG-AAML03P1 who are at high risk of having de novo Fanconi anemia.

- Procure diagnostic samples from the COG AML Biology Repository and identify Fanconi
anemia patients using western blot techniques.

OUTLINE: Previously collected cryopreserved cells are analyzed via western blot to identify
patients with Fanconi anemia.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Treated on COG-2961 or COG-AAML03P1

- At high risk of having Fanconi anemia, defined as meeting one the following groups of
clinical criteria:

- Group 1: Prolonged neutropenia after induction, severe regimen-related toxicity
(mucositis, veno-occlusive disease, end-organ damage)

- Group 2: Early non-relapse death (induction, consolidation)

- Group 3: Small-for-weight, secondary malignancies

PATIENT CHARACTERISTICS:

- Not specified

PRIOR CONCURRENT THERAPY:

- See Disease Characteristics

Type of Study:

Observational

Study Design:

N/A

Outcome Measure:

Identification of children at high risk of having Fanconi anemia

Safety Issue:

No

Principal Investigator

Monica S. Thakar, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Fred Hutchinson Cancer Research Center

Authority:

United States: Federal Government

Study ID:

CDR0000671437

NCT ID:

NCT01146210

Start Date:

October 2009

Completion Date:

Related Keywords:

  • Fanconi Anemia
  • Leukemia
  • Myelodysplastic Syndromes
  • Fanconi anemia
  • untreated childhood acute myeloid leukemia and other myeloid malignancies
  • childhood acute myeloblastic leukemia without maturation (M1)
  • childhood acute myeloblastic leukemia with maturation (M2)
  • childhood acute myelomonocytic leukemia (M4)
  • childhood acute monoblastic leukemia (M5a)
  • childhood acute monocytic leukemia (M5b)
  • childhood acute erythroleukemia (M6)
  • childhood acute megakaryocytic leukemia (M7)
  • refractory anemia with excess blasts in transformation
  • refractory anemia with excess blasts
  • refractory anemia with ringed sideroblasts
  • refractory anemia
  • chronic myelomonocytic leukemia
  • de novo myelodysplastic syndromes
  • secondary myelodysplastic syndromes
  • childhood myelodysplastic syndromes
  • childhood acute minimally differentiated myeloid leukemia (M0)
  • Anemia
  • Fanconi Anemia
  • Fanconi Syndrome
  • Leukemia
  • Leukemia, Myeloid, Acute
  • Leukemia, Myeloid
  • Myelodysplastic Syndromes
  • Preleukemia

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