Trial Information
Identification of de Novo Fanconi Anemia Patients Using FANCD2 Western Blots
OBJECTIVES:
- Identify children with newly diagnosed acute myeloid leukemia (AML) treated on COG-2961
and COG-AAML03P1 who are at high risk of having de novo Fanconi anemia.
- Procure diagnostic samples from the COG AML Biology Repository and identify Fanconi
anemia patients using western blot techniques.
OUTLINE: Previously collected cryopreserved cells are analyzed via western blot to identify
patients with Fanconi anemia.
Inclusion Criteria
DISEASE CHARACTERISTICS:
- Treated on COG-2961 or COG-AAML03P1
- At high risk of having Fanconi anemia, defined as meeting one the following groups of
clinical criteria:
- Group 1: Prolonged neutropenia after induction, severe regimen-related toxicity
(mucositis, veno-occlusive disease, end-organ damage)
- Group 2: Early non-relapse death (induction, consolidation)
- Group 3: Small-for-weight, secondary malignancies
PATIENT CHARACTERISTICS:
- Not specified
PRIOR CONCURRENT THERAPY:
- See Disease Characteristics
Type of Study:
Observational
Study Design:
N/A
Outcome Measure:
Identification of children at high risk of having Fanconi anemia
Safety Issue:
No
Principal Investigator
Monica S. Thakar, MD
Investigator Role:
Principal Investigator
Investigator Affiliation:
Fred Hutchinson Cancer Research Center
Authority:
United States: Federal Government
Study ID:
CDR0000671437
NCT ID:
NCT01146210
Start Date:
October 2009
Completion Date:
Related Keywords:
- Fanconi Anemia
- Leukemia
- Myelodysplastic Syndromes
- Fanconi anemia
- untreated childhood acute myeloid leukemia and other myeloid malignancies
- childhood acute myeloblastic leukemia without maturation (M1)
- childhood acute myeloblastic leukemia with maturation (M2)
- childhood acute myelomonocytic leukemia (M4)
- childhood acute monoblastic leukemia (M5a)
- childhood acute monocytic leukemia (M5b)
- childhood acute erythroleukemia (M6)
- childhood acute megakaryocytic leukemia (M7)
- refractory anemia with excess blasts in transformation
- refractory anemia with excess blasts
- refractory anemia with ringed sideroblasts
- refractory anemia
- chronic myelomonocytic leukemia
- de novo myelodysplastic syndromes
- secondary myelodysplastic syndromes
- childhood myelodysplastic syndromes
- childhood acute minimally differentiated myeloid leukemia (M0)
- Anemia
- Fanconi Anemia
- Fanconi Syndrome
- Leukemia
- Leukemia, Myeloid, Acute
- Leukemia, Myeloid
- Myelodysplastic Syndromes
- Preleukemia