Inclusion Criteria:

- Patients should have a histological diagnosis of primary ovarian, fallopian tube, or
primary peritoneal carcinoma and have undergone chemotherapy according.

- Initial attempted cytoreductive surgery must have been performed by gynecologic
oncologist with strict adherence to GOG surgical manual.

- End result of first surgery must have been optimal cytoreduction as defined as no
residual tumor ≥ 1cm.

- Patients should have clinical evidence of first recurrence. Two fold elevations in
CA125 or measurable tumor on CT scan constitute adequate evidence of recurrent
disease.

- Patients with the following primary tumor epithelial cell types are eligible: serous
adenocarcinoma, endometrioid adenocarcinoma, mucinous adenocarcinoma,
undifferentiated carcinoma, clear cell adenocarcinoma, adenocarcinoma (non-specific)
NOS, mixed epithelial carcinoma.

- Patients must have platin sensitive disease, defined as a recurrence occurring
greater than 6 months from cessation of original treatment.

- Patients must have a performance status of 0, 1, 2.

- Patients must have adequate bone marrow function as defined by an absolute neutrophil
count (ANC) ≥1500, platelet count ≥ 100,000, and a hemoglobin of greater than 10g/dl.

- Patients must have adequate renal function as defined by serum creatinine ≤ 1.5
mg/dl.

- Patients must have adequate hepatic function as defined by bilirubin ≤ 1.5 times
normal levels, alkaline phosphatase and SGOT ≤ 3 times normal levels.

- Patients who have signed an Institutional Review Board (IRB) approved informed
consent.

- Female patients 16-90 years of age.

- Patients must be deemed medically able to undergo a secondary surgical procedure.

Patient eligibility for systemic chemotherapy following HIPC:

- Patients must have successfully completed HIPC within 6 weeks of first prescribed
intravenous carboplatin and taxane cycle.

- Patients must have a performance status of 0, 1, or 2.

- Patients must have adequate bone marrow function as defined as an ANC ≥ 1500,
platelet count ≥ 100,000, and a hemoglobin of greater than 10g/dl.

- Patients must have adequate renal function as defined by serum creatinine ≤ 1.5
mg/dl.

- Patients must have adequate hepatic function as defined by bilirubin ≤ 1.5 times
normal levels, alkaline phosphatase and SGOT ≤ 3 times normal levels.

- Patients who have signed an IRB approved informed consent.

Exclusion Criteria:

- Patients with known recurrent disease outside the abdominal cavity.

- Patients with low malignant tumor at primary diagnosis as determined by pathologic
review.

- Patients with platin resistant disease as define as recurrence or progressive disease
prior to 6 months from completion of primary therapy.

- Patients with any evidence of another malignancy within the last 5 years with the
exception of non-melanoma skin cancer.

- Patients with evidence of concurrent septicemia, severe infection, renal failure, or
acute hepatitis.

- Patients with history of grade 3 or greater gastrointestinal bleeding.

- Patients with a GOG performance score of 3 or 4.

- Patients deemed medically unable to tolerate the HIPC procedure by care giving
physician.

- Patients with known allergy to platinum chemotherapy agents.

- Patients with equal to or greater than grade 2 neuropathy.