Inclusion Criteria:

- Phase I: Patients with diagnosis of multiple myeloma at any stage of disease
undergoing high dose chemotherapy and stem cell transplantation.

- Phase II: Patients with myeloma undergoing a first high dose chemotherapy and stem
cell transplantation after achieving at least stable disease following induction
therapy. Any induction regimen prior to transplantation is allowed. No more than 2
prior lines of therapy prior to transplantation are allowed.

- All previous therapy not associated with peripheral blood stem cell transplant,
including radiation, hormonal therapy, and surgery, must have been discontinued 4
weeks prior to treatment in this study.

- ECOG performance status of
- Laboratory test results within protocol-specified ranges

- All study participants must be registered into the mandatory RevAssist® program, and
be willing and able to comply with the requirements of RevAssist®

- Females of childbearing potential must have negative pregnancy test within 24 hours
of first prescription for lenalidomide and must commit to either continued abstinence
from heterosexual intercourse or begin TWO acceptable methods of birth control.

- Able to take aspirin daily as prophylactic anticoagulation

- Subject must have the minimum stem cell dose of 5.0 x 10^6 CD34+ cells/kg collected.

Exclusion Criteria:

- Pregnant or breast feeding females

- History of intolerance or resistance to lenalidomide

- Known hypersensitivity to thalidomide

- The development of erythema nodosum if characterized by a desquamating rash while
taking thalidomide or similar drugs.

- Known seropositive for or active viral infection with human immunodeficiency vrus
(HIV), hepatitis B virus (HBV) or hepatitis C virus (HCV). Patients who are
seropositive because of hepatitis b virus vaccine are eligible.