Implications of s-SHIP Expression and SHIP Alterations in AML
N/A
21 Years
Both
Leukemia
Trial Information
Implications of s-SHIP Expression and SHIP Alterations in AML
OBJECTIVES:
- Determine the extent and prognostic implications of variable s-SHIP expression and SHIP
gene mutations in pediatric patients with acute myeloid leukemia.
- Determine the effects of aberrant s-SHIP expression on the PI3K/Akt pathway in these
patients via electrochemiluminescence and phosphospecific flow cytometry assays.
OUTLINE: RNA samples are analyzed for variable s-SHIP expression and are screened for SHIP
mutations. Cryopreserved cells (with known high- or low-s-SHIP expression) are analyzed for
the levels of various components of the PI3K/Akt pathway via electrochemiluminescence and
phosphospecific flow cytometry.
Inclusion Criteria
DISEASE CHARACTERISTICS:
- Diagnosis of acute myeloid leukemia
PATIENT CHARACTERISTICS:
- Not specified
PRIOR CONCURRENT THERAPY:
- Not specified
Type of Study:
Observational
Study Design:
N/A
Outcome Measure:
Event-free survival
Safety Issue:
No
Principal Investigator
Phoenix Ho, MD
Investigator Role:
Principal Investigator
Investigator Affiliation:
Fred Hutchinson Cancer Research Center
Authority:
United States: Federal Government
Study ID:
CDR0000671462
NCT ID:
NCT01138306
Start Date:
September 2009
Completion Date:
Related Keywords:
- Leukemia
- childhood acute myeloid leukemia/other myeloid malignancies
- Leukemia
- Leukemia, Myeloid, Acute
- Leukemia, Myeloid
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