Trial Information

Dual-time PET/CT and Sentinel Node Diagnostics Preoperatively in Patients With Oral Cancer

These patients are normally preoperatively sent to a CT scan of the thorax and abdomen; in
this study, this CT is replaced by a wholebody PET/CT scan. Afterwards, the patients goes to
sentinel node lymphoscintigraphy and then to operation.

By combining biomarkers and molecular imaging in patients with a clinically T1/T2N0M0 oral
cancer, we want to characterize the tumor physiologically and correlate these physiological
features to the clinical appearance of the cancer.

Aims of the study:

- can PET/CT in this patient group metastases with consequently change of treatment?

- can fusion of SPECT/CT and PET/CT with calculation of standardized uptake value (SUV)
indicate, how much tumor tissue there should be in a positive sentinel node to be
detected by PET?

- can dual-time PET scanning better determine lymph node metastases, than single-time PET
scanning?

- correlation between SUV in PET with molecular-biological findings both in the primary
tumor and in metastases