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Dual-time PET/CT and Sentinel Node Diagnostics Preoperatively in Patients With Oral Cancer

18 Years
Open (Enrolling)
Oral Cancer

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Trial Information

Dual-time PET/CT and Sentinel Node Diagnostics Preoperatively in Patients With Oral Cancer

These patients are normally preoperatively sent to a CT scan of the thorax and abdomen; in
this study, this CT is replaced by a wholebody PET/CT scan. Afterwards, the patients goes to
sentinel node lymphoscintigraphy and then to operation.

By combining biomarkers and molecular imaging in patients with a clinically T1/T2N0M0 oral
cancer, we want to characterize the tumor physiologically and correlate these physiological
features to the clinical appearance of the cancer.

Aims of the study:

- can PET/CT in this patient group metastases with consequently change of treatment?

- can fusion of SPECT/CT and PET/CT with calculation of standardized uptake value (SUV)
indicate, how much tumor tissue there should be in a positive sentinel node to be
detected by PET?

- can dual-time PET scanning better determine lymph node metastases, than single-time PET

- correlation between SUV in PET with molecular-biological findings both in the primary
tumor and in metastases

Inclusion Criteria:

- biopsy-verified oral cancer

- over 18 years of age

Exclusion Criteria:

- under 18 years of age

- inable patients

- pregnancy

- known allergy to contrast agents

- kidney insufficiency

- other known cancer

- diabetes mellitus

- acute medical conditions such as acute infection, acute cardial or lung disease or
other intercurrent diseases

Type of Study:


Study Design:

Observational Model: Case-Only, Time Perspective: Prospective

Principal Investigator

Christine W D├╝mcke, Dr.

Investigator Role:

Principal Investigator

Investigator Affiliation:

Dep. of Nuclear Medicine & PET


Denmark: National Board of Health

Study ID:




Start Date:

June 2010

Completion Date:

June 2013

Related Keywords:

  • Oral Cancer
  • dual-time PET/CT
  • sentinel node
  • Mouth Neoplasms
  • Lip Neoplasms