Human Glioblastoma Multiforme (GBM) Circulating Tumor Cells (CTCs) as Early, Less Invasive Markers of Progression and Response
Despite aggressive therapies, Glioblastoma Multiforme (GBM) is rapidly fatal. GBMs are
increasingly recognized for occasionally metastasizing through the peripheral blood to
distant locations. This research study involves the detection and novel characterization of
human GBM (hGBM) circulating tumor cells (CTCs) within the peripheral blood of brain tumor
patients by identifying their unique cell surface antigen profile, determining an optimal
isolation protocol, and quantitatively and qualitatively reporting the yield and
Observational Model: Case Control, Time Perspective: Prospective
Identification of Human GBM CD Antigen Signature.
Already established and stored GBM cell lines will be screened for CD antigens to confirm that a selective cell surface antigen can be identified.
Erin M Dunbar, MD
University of Florida
United States: Institutional Review Board
|University of Florida||Gainesville, Florida 32610-0277|