Inclusion Criteria:

1. Age : older than 18

2. Histologically confirmed adenocarcinoma of the biliary tract

3. Metastatic or unresectable biliary cancer

4. Prior exposure to gemcitabine chemotherapy for biliary cancer

5. Eastern Cooperative Oncology Group (ECOG) performance status 0 -2

6. A patient with at least one measurable primary lesion of which the diameter is
confirmed to be 10mm in spiral Computed Tomography (CT) or multidetector CT

7. Adequate bone marrow, liver, renal function

Exclusion Criteria:

1. Pregnancy and breast-feeding.

2. Other serious illness or medical condition, notably heart or lung failure, active
uncontrolled infection (infection requiring antibiotics).

3. Past or concurrent history of other neoplasm, except curatively treated basal cell
skin cancer or adequately treated in-situ carcinoma of the cervix.

4. Symptomatic or uncontrolled brain metastasis