Ages Eligible for Study: Between 60 and 80 years old

Genders Eligible for Study: Both

Accepts Healthy Volunteers: No

Inclusion Criteria:

For patients registered at the time of initial diagnosis

- Patient with histologically proven CD20+ diffuse large B cel LYMPHOMA (DLBCL) 5WHO
classification 2008) including clinical subtypes (primitive mediastinal,
intravascular, etc.). Patients with De Novo Transformed DLBCL from low grade lymphoma
(Follicular, other..) may also be included. Patients with DLBCL associated with some
small cell infiltration in bone marrow may also be included Or CD20+ B-cell lymphoma
with intermediate features between DLBCL and Burkitt or with intermediate features
between DLBCL and classical Hodgkin lymphoma Or CD20+ Follicular lymphoma grade 3B Or
CD20+ Aggressive B-cell lymphoma unclassifiable

- previous untreated with chemo- or radiotherapy

For patients registered after response evaluation to first line treatment with R-CHOP:

- Patient with histologically proven CD20+ diffuse large B cell LYMPHOMA (DLBCL) 5WHO
classification 2008) including clinical subtypes (primitive mediastinal,
intravascular, etc.). Patients with De Novo Transformed DLBCL from low grade lymphoma
(Follicular, other..) may also be included. Patients with DLBCL associated with some
small cell infiltration in bone marrow may also be included Or CD20+ B-cell lymphoma
with intermediate features between DLBCL and Burkitt or with intermediate features
between DLBCL and classical Hodgkin lymphoma Or CD20+ Follicular lymphoma grade 3B Or
CD20+ Aggressive B-cell lymphoma unclassifiable

- Have reached a CR or PR after first line treatment with at least 6 cycles of R-CHOP
14 regimens and up to 8 cycles of R-CHOP21

- Previously untreated with Radiotherapy

For all patients:

- aged from 60 to 80 years at time of registration

- Ann Arbor stages II-IV at time of initial diagnosis

- aaIPI> 1 at time of initial diagnosis

- ECOG performance status 0-2

- Minimum life expectancy of 3 months

- Following laboratory values at screening:

- ANC≥ 1000.10^6/L and Platelets≥60000.10^6/L

- AST<5*ULN, ALT<5*ULN, Total Bilirubin<1,5*ULN

- Creatinine clearance>30mL/min

- Women are are using effective contraception, are not pregnant and agree not to become
pregnant during participation in the trial and after end of study. Men agree not to
father a child during participation in the trial and during the 12 months thereafter.

- Having previously signed a written informed consent form

Exclusion Criteria:

- Any other histological type of Lymphoma, Burkitt included.

- Any history of treated or non treated small B-cell lymphoma

- Central nervous system or meningeal involvement by lymphoma

- Contraindication to any drug contained in the chemotherapy regimen Myocardial
infarction during last 3 months or unstable coronary disease or uncontrolled chronic
symptomatic congestive heart insufficiency NYHA III-IV

- Uncontrolled hypertension

- Uncontrolled diabetes mellitus as defined by the investigator

- Active systemic infection requiring treatment

- previously known HIV positive serology

- Active hepatitis B or C

- Prior history of malignancies other than lymphoma within 3 years

- Serious medical or psychiatric illness