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Childhood Cancer Survivor Study

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Trial Information

Childhood Cancer Survivor Study

The study will focus on the following objectives:

- Characterize survivors' health with respect to disease- and treatment-related factors.

- Investigate the consequences of various intensities of exposure to chemotherapy and/or
radiation on health outcomes (e.g., cardiovascular, reproductive, second cancers,

- Compare the mortality experience of survivors with the general population.

- Characterize the health-related behaviors, patterns of medical care, and medical
follow-up needs of survivors.

- Describe patterns of familial aggregation of cancer, including known (and variations
of) cancer family syndromes.

- Collect and store biologic samples (saliva, blood, second tumor tissue) to correlate
with health outcomes and use for future research.

Inclusion Criteria:

Initial Cohort:

- Five-year survival following diagnosis of leukemia, lymphoma, CNS tumor, bone tumor,
Wilms tumor, neuroblastoma, or soft tissue sarcoma before age 21 years between
January 1, 1970 and December 31, 1986 at one of participating centers.

Expanded cohort:

- Five-year survival following diagnosis of leukemia, lymphoma, CNS tumor, bone tumor,
kidney tumor, neuroblastoma, or rhabdomyosarcoma before age 21 years between January
1, 1987 and December 31, 1999 at one of participating centers.

- English- or Spanish-speaking and living in the U.S. or Canada at the time of

Exclusion Criteria:

- Diagnosis of non-malignant tumors (i.e., Langerhans cell histiocytosis, meningioma,
craniopharyngioma, etc.) treated with radiation and/or chemotherapy.

- Non-English speaking or residence outside the US or Canada.

Sibling Controls:

- For comparison purposes, a group of sibling controls will be identified to represent
a stratified random sample based on the distribution of survivors with regard to
cancer diagnosis, age, sex, race, and geographic location.

Type of Study:


Study Design:

Observational Model: Cohort, Time Perspective: Retrospective

Outcome Measure:

To characterize survivors' health outcomes with respect to disease-, treatment, and genetic-related factors.

Outcome Time Frame:

25 years

Safety Issue:


Principal Investigator

Les Robison, Ph.D

Investigator Role:

Principal Investigator

Investigator Affiliation:

St. Jude Children's Research Hospital


United States: Institutional Review Board

Study ID:




Start Date:

March 1994

Completion Date:

March 2019

Related Keywords:

  • Cancer
  • Childhood cancer
  • Young Children
  • Adults



Roswell Park Cancer Institute Buffalo, New York  14263
Children's Hospital of Philadelphia Philadelphia, Pennsylvania  19104
Dana-Farber Cancer Institute Boston, Massachusetts  02115
Children's Hospital Los Angeles Los Angeles, California  90027-0700
Children's National Medical Center Washington, District of Columbia  20010-2970
Children's Hospital of Pittsburgh Pittsburgh, Pennsylvania  15213
City of Hope National Medical Center Los Angeles, California  91010
Nationwide Children's Hospital Columbus, Ohio  43205-2696
Stanford University School of Medicine Stanford, California  94305-5317
University of Minnesota Minneapolis, Minnesota  55455
University of California-San Francisco San Francisco, California  94143
M.D. Anderson Cancer Center Houston, Texas  77030
University of Texas Southwestern Medical Center Dallas, Texas  
Texas Children's Hospital Houston, Texas  
Memorial-Sloan Kettering Cancer Center New York, New York  10021-6007
Seattle Children's Hospital Seattle, Washington  98105
University of California-Los Angeles Los Angeles, California  90095
Indiana University/Riley Hospital for Children Indianapolis, Indiana  46202
St . Jude Children's Research Hospital Memphis, Tennessee  38105
University of Alabama at Birmingham/Children's of Alabama Birmingham, Alabama  35294
Children's Hospital Colorado Aurora, Colorado  80045
Emory University/Children's Health Care of Atlanta Atlanta, Georgia  30322
University of Michigan/Mott Children's Hospital Ann Arbor, Michigan  48109
Children's Hospitals & Clinics of Minnesota Minneapolis, Minnesota  55404
St. Louis Children's Hospital/The Washington University St. Louis, Missouri  63130