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Childhood Cancer Survivor Study


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Open (Enrolling)
Both
Cancer

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Trial Information

Childhood Cancer Survivor Study


The study will focus on the following objectives:

- Characterize survivors' health with respect to disease- and treatment-related factors.

- Investigate the consequences of various intensities of exposure to chemotherapy and/or
radiation on health outcomes (e.g., cardiovascular, reproductive, second cancers,
etc…).

- Compare the mortality experience of survivors with the general population.

- Characterize the health-related behaviors, patterns of medical care, and medical
follow-up needs of survivors.

- Describe patterns of familial aggregation of cancer, including known (and variations
of) cancer family syndromes.

- Collect and store biologic samples (saliva, blood, second tumor tissue) to correlate
with health outcomes and use for future research.


Inclusion Criteria:



Initial Cohort:

- Five-year survival following diagnosis of leukemia, lymphoma, CNS tumor, bone tumor,
Wilms tumor, neuroblastoma, or soft tissue sarcoma before age 21 years between
January 1, 1970 and December 31, 1986 at one of participating centers.

Expanded cohort:

- Five-year survival following diagnosis of leukemia, lymphoma, CNS tumor, bone tumor,
kidney tumor, neuroblastoma, or rhabdomyosarcoma before age 21 years between January
1, 1987 and December 31, 1999 at one of participating centers.

- English- or Spanish-speaking and living in the U.S. or Canada at the time of
diagnosis.

Exclusion Criteria:

- Diagnosis of non-malignant tumors (i.e., Langerhans cell histiocytosis, meningioma,
craniopharyngioma, etc.) treated with radiation and/or chemotherapy.

- Non-English speaking or residence outside the US or Canada.

Sibling Controls:

- For comparison purposes, a group of sibling controls will be identified to represent
a stratified random sample based on the distribution of survivors with regard to
cancer diagnosis, age, sex, race, and geographic location.

Type of Study:

Observational

Study Design:

Observational Model: Cohort, Time Perspective: Retrospective

Outcome Measure:

To characterize survivors' health outcomes with respect to disease-, treatment, and genetic-related factors.

Outcome Time Frame:

25 years

Safety Issue:

No

Principal Investigator

Les Robison, Ph.D

Investigator Role:

Principal Investigator

Investigator Affiliation:

St. Jude Children's Research Hospital

Authority:

United States: Institutional Review Board

Study ID:

CCSS

NCT ID:

NCT01120353

Start Date:

March 1994

Completion Date:

March 2019

Related Keywords:

  • Cancer
  • Childhood cancer
  • Young Children
  • Adults

Name

Location

Roswell Park Cancer InstituteBuffalo, New York  14263
Children's Hospital of PhiladelphiaPhiladelphia, Pennsylvania  19104
Dana-Farber Cancer InstituteBoston, Massachusetts  02115
Children's Hospital Los AngelesLos Angeles, California  90027-0700
Children's National Medical CenterWashington, District of Columbia  20010-2970
Children's Hospital of PittsburghPittsburgh, Pennsylvania  15213
City of Hope National Medical CenterLos Angeles, California  91010
Nationwide Children's HospitalColumbus, Ohio  43205-2696
Stanford University School of MedicineStanford, California  94305-5317
University of MinnesotaMinneapolis, Minnesota  55455
University of California-San FranciscoSan Francisco, California  94143
M.D. Anderson Cancer CenterHouston, Texas  77030
University of Texas Southwestern Medical CenterDallas, Texas  
Texas Children's HospitalHouston, Texas  
Memorial-Sloan Kettering Cancer CenterNew York, New York  10021-6007
Seattle Children's HospitalSeattle, Washington  98105
University of California-Los AngelesLos Angeles, California  90095
Indiana University/Riley Hospital for ChildrenIndianapolis, Indiana  46202
St . Jude Children's Research HospitalMemphis, Tennessee  38105
University of Alabama at Birmingham/Children's of AlabamaBirmingham, Alabama  35294
Children's Hospital ColoradoAurora, Colorado  80045
Emory University/Children's Health Care of AtlantaAtlanta, Georgia  30322
University of Michigan/Mott Children's HospitalAnn Arbor, Michigan  48109
Children's Hospitals & Clinics of MinnesotaMinneapolis, Minnesota  55404
St. Louis Children's Hospital/The Washington UniversitySt. Louis, Missouri  63130