Inclusion Criteria:

1. Inoperable locally advanced gall bladder and pancreatic cancer by virtue of vascular
encasement of superior mesenteric artery (SMA), celiac artery, hepatic artery, portal
vein (PV) or deep hilar invasion precluding R0 resection.

2. Biopsy proven adenocarcinoma

3. KPS >= 70

4. Age >18 years

5. Medically fit for chemotherapy

6. Normal hematological, renal and hepatic function (Serum Bilirubin<3mg/dl)

7. No prior history of treatment with radiation or chemotherapy.

8. Patient willing and reliable for follow-up.

Exclusion criteria

1. Any other malignancy in any site.

2. Expected survival < 3months.

3. Severe co-morbid conditions ( Severe cardiac disorder, severe bronchial asthma,
severely compromised liver function, psychological disorder)

4. Malignant ascitis.

5. Distant metastases by clinical examination or by imaging/whole bodyPET scan.