Inclusion Criteria:

- Diagnosis of Advanced Hepatocellular carcinoma

- Asian ethnicity

- Patient has failed ≥ 14 days of sorafenib treatment

- Cirrhotic status of Child-Pugh Class A or B with a score of 7

- ECOG performance status 0,1,2

- Subjects who have a life expectancy of at least 8 weeks

- Adequate hematologic, hepatic, and renal function

Exclusion Criteria:

- WOCBP who are unwilling or unable to use an acceptable method to avoid pregnancy

- Previous or concurrent cancer that is distinct in primary site

- History of active cardiac disease

- Thrombotic or embolic events within the past 6 months

- Inability to swallow tablets or untreated malabsorption syndrome

- History of human immunodeficiency virus (HIV) infection

- Prior use of systemic investigational agents for HCC (except for Sorafenib)