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Molecular Analysis of Samples From Patients With Diffuse Intrinsic Pontine Glioma and Brainstem Glioma

21 Years
Open (Enrolling)
Diffuse Intrinsic Pontine Glioma, Brainstem Glioma

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Trial Information

Molecular Analysis of Samples From Patients With Diffuse Intrinsic Pontine Glioma and Brainstem Glioma

High grade diffuse intrinsic pontine glioma (DIPG) accounts for approximately 80% of
pediatric brainstem tumors and 10% of pediatric brain tumors, and is the most lethal form of
brainstem gliomas in children. There is currently no effective therapy to treat these
tumors. We hypothesize that this tumor exhibits unique molecular abnormalities leading to
altered RNA and protein expression. The aim of this trial is to collect specimens from
pediatric patients with diffuse intrinsic pontine glioma including serum, cerebrospinal
fluid, urine, brain tumor and other constitutional tissue, during therapy and/or at autopsy.
Our goal is to study this tissue to characterize the genetic abnormalities that lead to
tumor formation in order to identify key molecules as biomarkers which we can target to
design and test new and more effective treatments.

Inclusion Criteria:

- Patients of any age with clinical and radiologic diagnosis of diffuse intrinsic
pontine glioma

- Patients with other high-grade gliomas originating in the brainstem

- Patients with focal gliomas (WHO grade I/II) of the brainstem

Exclusion Criteria:

- Patients with any type of infiltrative low grade (WHO grade I and II) or high grade
glioma (WHO grade III and IV) originating outside the brainstem

- Patients harboring primary brainstem tumors with other histologic diagnoses (e.g.,

Type of Study:


Study Design:

Observational Model: Cohort, Time Perspective: Prospective

Outcome Measure:

Genome-wide expression patterns of RNA in tumor samples, normal brainstem tissue and cerebrospinal fluid using Affymetrix gene expression profiling

Outcome Time Frame:

4 years

Safety Issue:


Principal Investigator

Javad Nazarian, PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Children's Research Institute


United States: Institutional Review Board

Study ID:




Start Date:

April 2010

Completion Date:

April 2014

Related Keywords:

  • Diffuse Intrinsic Pontine Glioma
  • Brainstem Glioma
  • diffuse intrinsic pontine glioma
  • DIPG
  • childhood brainstem glioma
  • pediatric brainstem glioma
  • brainstem glioma
  • BSG
  • Glioma
  • Pontine Glioma



Children's National Medical Center Washington, District of Columbia  20010-2970