Inclusion Criteria:

1. Have multiple myeloma in Stage II or III, according to the criteria of Durie and
Salmon.

2. Male or female between 18 and 70 years of age, inclusive. Male and females capable
of reproduction must agree to use adequate contraceptive measures (e.g. condom,
intrauterine device, oral contraceptive) until 3 months after termination of
treatment.

3. Measurable disease, defined by one of the following:

- Serum M protein ≥1.0 g/dL by protein electrophoresis

- Quantifiable immunoglobulin levels and/or

- urinary M protein excretion ≥200 mg/24 hours.

4. All patients have undergone 3 cycles of chemotherapy, with the last dose of
chemotherapy given 3 to 8 weeks before study entry.

5. Eastern Cooperative Oncology Group (ECOG) performance status of 2.

6. Life expectancy of >6 months.

7. Have given their written informed consent to participate in the study

Exclusion Criteria:

1. Have non-secretory myeloma and/or plasma cell leukaemia.

2. History of other malignancies during the past 5 years, with the exception of
adequately treated basal or squamous cell carcinoma of the skin, cervical carcinoma,
or localised prostate carcinoma.

3. Any other clinically significant medical conditions.

4. History of cardiac disease NHYA classification ≥3.

5. Insufficient bone marrow, liver and renal function as assessed by the following
clinical laboratory evaluations:

Haemoglobin <9.0 g/L. Absolute neutrophil count <1500/µL. Platelet count <50000/µL.
Total bilirubin >1.5 x upper limit of normal (ULN). Alanine aminotransferase (ALT)
and alkaline phosphatase (AP) >2.5 x ULN. Amylase and lipase >1.5 x ULN. Serum
creatinine >2.0 x ULN. Prothrombin time (PT) and activated partial thrombo-plastin
time (aPTT) >1.5 x ULN.

6. Pregnant or lactating female patients.

7. Known history of HIV infection or chronic hepatitis B or C infection.

8. Receipt of immunotherapy, radiation therapy, or any investigational drug within 30
days of study drug administration.

9. Prior radiotherapy to more than 3 vertebrae.

10. Active serious bacterial or fungal infections; >grade 3 National Cancer Institute
(NCI) Common Terminology Criteria for Adverse Events (CTCAE).

11. Receipt of haematopoietic cytokines within 10 days of study drug administration.