Inclusion Criteria:

1. Informed consent explained and signed prior to any study related procedures.

2. Age ≥18 years

3. Eastern Cooperative Oncology Group (ECOG) performance status of 2 or better, or
Karnofsky performance of 60% or better.

4. Histologically confirmed adenocarcinoma of the prostate within 10 years of study
entry.

5. Willingness to return to Mayo Clinic Rochester for follow-up or participate in
mail-in PSA processing.

6. Must be disease-free from a previous diagnosis of cancer for a period of time = 5
years excluding cutaneous malignancies of squamous cell or basal cell carcinoma.

Exclusion Criteria:

1. Life expectancy < 5 years.

2. Inability to return to Mayo Rochester for follow-up appointments, sera, and urine
collection per protocol.

3. Previous or a concurrent diagnosis of cancers other than basal cell or invasive
squamous cell carcinoma of skin within the past 5 years.