Orthotopic Propagation of Primary Human Ovarian Tumors for Preclinical Investigation of Novel Anti-Tumor Agents.
- To generate a translational ovarian cancer model using tumor tissue and cells from
patients with stage III-IV ovarian/primary peritoneal/fallopian tube epithelial cancer
for drug response and development.
OUTLINE: Tissue and fluid samples are collected at the time of surgery or paracentesis and
used in laboratory experiments and in animal models. Health data is collected from patient
medical records before, during, and after surgery.
After surgery, patients are followed up for 5 years.
Observational Model: Cohort, Time Perspective: Prospective
Establishment of a "live" library of primary ovarian epithelial tumors
Our approach is to establish a "live" library of primary tumors from patients diagnosed with ovarian cancer by transplanting this tissue into a host mouse model. This preclinical model system will allow us to test the response to standard and novel therapeutics and will provide a perpetual tumor archive for future experiments that will probe critical molecular pathways involved in the pathogenesis of ovarian cancer and similar cancer types (primary peritoneal and fallopian tube).
5 year follow up of outcome.
Dineo Khabele, MD
Vanderbilt-Ingram Cancer Center
United States: Federal Government
|Vanderbilt-Ingram Cancer Center||Nashville, Tennessee 37232-6838|