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Procedures of Locoregional Analgesia and Quality of Life in Palliative Care

18 Years
Open (Enrolling)

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Trial Information

Procedures of Locoregional Analgesia and Quality of Life in Palliative Care

Cancer pain is a serious problem in the palliative population. In particular, pain due to
compression or invasion of nerve tissue by metastasis is frequent and often unresponsive to
oral drug therapy and even to epidural administration of opioids. In such refractory pain in
a palliative setting, one modality that could be helpful is the use of technics of
locoregional analgesia. Currently, they are routinely used for the management of acute
postoperative pain and become to be more widely used for cancer surgery. For example,
intrapleural intercostal nerve blocks after major lung resection or preincisional
paravertebral blocks after breast surgery have been shown to improve pain control. However,
locoregional analgesia is only occasionally used in chronic cancer pain.

The procedures used are epidural analgesia, rachianesthesia, or continuous nerve blocks.
L-bupivacaine will be used. The procedure will be performed only if the injection test is

The patients will be evaluated before and after the procedure, the patient being his/her own
control. Evaluations will take place immediately before the procedure, then at 48 hours, 1
week and 1 month after the procedure.

Inclusion Criteria:

- Patient ≥ 18 years-old, male or female, whatever his/her ethnic group

- Patient with untreatable cancer

- Patient hospitalized in a palliative care unit, with a life expectancy ≥ 1 week

- Pain unresponsive to conventional treatments

- Effectiveness of the injection test

- Signed informed consent

Exclusion Criteria:

- Patients > 18 years-old

- Patients with pain other than cancer pain

- Patient's refusal

- Coagulation disorders

- Local infection

- Known hypersensitivity to local analgesics

- Inefficacy of the injection test.

- Contraindication for analgesics

Type of Study:


Study Design:

Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Supportive Care

Outcome Measure:

Change in patients global quality of life

Outcome Description:

To evaluate the change in patients global quality of life, assessed by the item 15 of the validated quality of life scale EORTC QLQ-C15 PAL. Evaluations will take place before the procedure of locoregional analgesia and 1 week after.

Outcome Time Frame:

1 week after first injection

Safety Issue:


Principal Investigator


Investigator Role:

Study Chair

Investigator Affiliation:

CHU Limoges


France: Afssaps - Agence française de sécurité sanitaire des produits de santé (Saint-Denis)

Study ID:




Start Date:

April 2010

Completion Date:

April 2014

Related Keywords:

  • Pain
  • Cancer pain