Inclusion Criteria:

- The patient must, according with investigator criteria, be able to comply with all
the protocol requirements

- The patient or legal representative must sign voluntarily the informed consent before
the performance of any study related procedure, not part of usual medical care, with
the knowledge that can leave the study the moment he/she wants, without prejudice to
later medical care

- 18 years and older

- Patients with newly diagnosed symptomatic multiple myeloma43 which hasn`t been
treated previously with any chemotherapy used for this disease (see Annex 8)

- Patient with a measurable or evaluable disease, defined as follows:

- For secretor multiple myeloma, measurable disease is defined as any quantifiable
serum monoclonal protein value of IgG>10g/l or IgA > 5 g/l and, where
applicable, urine light-chain excretion of ≥ 200 mg/24 hours

- For oligo or non-secretor multiple myeloma, measurable disease is defined by the
presence of soft tissue plasmocytomas (not bone) determined by clinical
examination or applicable radiographs (i.e. MRI, CT-Scan). In patients with low
secretor multiple myeloma, the serum and/or urine M-protein measurements are
very low and difficult to follow for response assessment. In patients with
non-secretor multiple myeloma, there is no M-protein in serum or urine by
immunofixation

- ECOG performance status ≤ 2 (see Appendix 5)

- Patient has a life-expectancy >3 months

- Glomerular filtration calculated with MDRD <50 ml/min

- Patient has the following laboratory values during the 14 days before first dose:

- Platelet count ≥ 50x109/l

- Absolute neutrophil count (ANC) ≥ 0.75 x 10 9/ L

- Corrected serum calcium (see Appendix 15) ≤ 14mg/dl

- Aspartate transaminase (AST): ≤ 2,5 x upper limit of normal

- Alanine Aminotransferase (ALT): ≤ 2,5 x upper limit of normal

- Total bilirubin: ≤ 1,5 x upper limit of normal

Exclusion Criteria:

- Glomerular filtration calculated with MDRD ≥ 50ml/min

- Asymptomatic MM with renal failure from unrelated causes

- Prior Velcade therapy

- Patients previously received treatment to Multiple Myeloma

- Patient had major surgery within 4 weeks previous inclusion

- Patient with platelet count ≤ 50 x 109/l within 14 days before enrolment

- Patient with absolute neutrophil count ≤ 0,75x109/l within 14 days before enrolment

- Patients with Grade 2 peripheral neuropathy within 14 days before enrolment

- Patient has hypersensitivity to bortezomib, boron or mannitol

- Patient has received other investigational drugs within 14 days before enrolment

- Patient is known to be seropositive for the human immunodeficiency virus (HIV)

- Patient had a myocardial infarction within 6 months before of enrolment or has Class
III or IV heart failure (New York Heart Association ), uncontrolled angina,
severe uncontrolled ventricular arrhythmias, or electrocardiography evidence of acute
ischemia or active conduction system abnormalities, or other heart condition which,
according with the specialist, can result in heart failure

- Patient is enrolled in another clinical research study and/or is receiving an
investigational agent for any reason

- Patients with diffuse pulmonary disease and/or pericardial disease

- Pregnancy or breast-feed women and women of childbearing age that don't accept to use
anticonceptive methods since beginning during all the study until 30 days after last
cycle treatment. Fertile male patients must use effective form of contraception since
enrolment, during and until 30 days after last cycle study treatment

- Patient with a previous clinical history of another malign illness except for
squamous cell carcinoma or skin cancer or cervical or breast cancer) except the
patient could be free of symptoms during ≥ 5 years

- Uncontrolled arterial hypertension or diabetes mellitus or other serious medical
condition which places the subject at unacceptable risk or other psychiatric illness
that would prevent the subject from understanding the informed consent form