Inclusion Criteria:

- MDS, CMML or AML patients (as diagnosed by World Health Organization [WHO] criteria)
with evidence of relapse or progression at >= day 28 and < day 100 post-transplant

- Recurrent or increased cytogenetic abnormalities by standard karyotype or
fluorescence in situ hybridization (FISH) (the cytogenetic abnormalities must have
been previously documented at some time point between diagnosis and date of stem cell
transplant)

- Morphologic evidence of recurrence or increased abnormal myeloblasts in peripheral
blood or marrow

- Flow Cytometric evidence of disease as determined by recurrent or increased abnormal
myeloblasts in peripheral blood or marrow

- Extramedullary relapse (local radiotherapy will be allowed)

- MDS, CMML, or AML patients with persistent stable disease or persistent disease with
regression at >= day 28 and < day 100 post-transplant; the inclusion of patients with
persistent stable or persistent regressing disease in this protocol is not meant to
advocate treatment; however, if the attending physician is inclined to offer
treatment then these patients would be eligible for this study

- Persistence of cytogenetic abnormalities by standard karyotype or FISH

- Persistent morphologic evidence of abnormal myeloblasts (in patients with CMML the
monoblastoid population is included) in peripheral blood or marrow

- Persistent flow cytometric evidence of abnormal myeloblasts (in patients with CMML
the monoblastoid population is included) in peripheral blood or marrow

- Extramedullary persistence or regression

Exclusion Criteria:

- Refractory disease at time of stem cell transplant; patients who received
chemotherapy prior to transplant with no evidence of response by International
Working Group (IWG) criteria

- >= 10% bone marrow myeloblasts as measured by morphology

- Evidence of central nervous system (CNS) disease at time of relapse by morphology or
flow (a diagnostic lumbar puncture [LP] is not required at time of relapse)

- Serum creatinine > 2 x ULN (upper limit of normal)

- Aspartate aminotransferase (AST)/ alanine aminotransferase (ALT) > 2x ULN

- Performance status > 2 (Eastern Cooperative Oncology Group [ECOG] Scale)

- Patients with severe disease other than MDS, CMML or AML which would be expected to
prevent compliance with treatment

- Patients with severe infections (pneumonia, sepsis, etc) within the 2 weeks prior to
the anticipated start of protocol treatment