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Target Identification for High Risk Childhood AML Based on Genome-Wide Analysis


N/A
N/A
21 Years
Open (Enrolling)
Both
Leukemia

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Trial Information

Target Identification for High Risk Childhood AML Based on Genome-Wide Analysis


OBJECTIVES:

- To determine whether the detailed mapping of transcription, gene copy number, loss of
heterozygosity status, and genomic methylation patterns will reveal novel changes that
can refine risk-group stratification and be therapeutically targeted in pediatric
patients with high-risk acute myeloid leukemia.

OUTLINE: This is a multicenter study.

Banked bone marrow samples from diagnosis and remission are used to develop a detailed
molecular map of pediatric high-risk acute myeloid leukemia. Analysis includes genome SNP
genotyping, expression, and methylation profiling.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Diagnosis of acute myeloid leukemia

- High-risk disease

- Treated on COG-AAML03P1 or COG-AAML0531

- Meets the following criteria:

- Initial remission with no known adverse risk factors

- High quantity and quality of RNA and DNA available

- Highly enriched specimens with ≥ 50% blast available

PATIENT CHARACTERISTICS:

- Not specified

PRIOR CONCURRENT THERAPY:

- See Disease Characteristics

Type of Study:

Observational

Study Design:

N/A

Outcome Measure:

Detailed molecular map of pediatric high-risk acute myeloid leukemia

Safety Issue:

No

Principal Investigator

Soheil Meshinchi, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Fred Hutchinson Cancer Research Center

Authority:

United States: Federal Government

Study ID:

CDR0000666492

NCT ID:

NCT01076569

Start Date:

March 2010

Completion Date:

Related Keywords:

  • Leukemia
  • recurrent childhood acute myeloid leukemia
  • childhood acute monocytic leukemia (M5b)
  • childhood acute megakaryocytic leukemia (M7)
  • childhood acute minimally differentiated myeloid leukemia (M0)
  • childhood acute myeloblastic leukemia with maturation (M2)
  • childhood acute myeloblastic leukemia without maturation (M1)
  • childhood acute myelomonocytic leukemia (M4)
  • childhood acute monoblastic leukemia (M5a)
  • childhood acute erythroleukemia (M6)
  • untreated childhood acute myeloid leukemia and other myeloid malignancies
  • childhood acute basophilic leukemia
  • childhood acute eosinophilic leukemia
  • Leukemia
  • Leukemia, Myeloid, Acute
  • Leukemia, Myeloid

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