Vitamin D Production Depends on Ultraviolet-B Dose But Not on UV-intensity. A Randomized Controlled Trial
18 Years
65 Years
Both
Vitamin D Status
Trial Information
Vitamin D Production Depends on Ultraviolet-B Dose But Not on UV-intensity. A Randomized Controlled Trial
The work is addressing vitamin D production after UVB exposure and explore the importance of
UVB dose and UV intensity. Four different UVB doses and four different UV intensities are
used to explore these relationships.
Many assumptions have been made concerning the vitamin D production after UVB exposure but
only few studies exist.
Inclusion Criteria:
- 18-65 years
- Healthy
Exclusion Criteria:
- Sun bed use
- Holiday or business travel south of 45 degrees latitude during trial
- Illness
- Drug addiction
- Pregnancy
- Lactating
Type of Study:
Interventional
Study Design:
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Basic Science
Outcome Measure:
Vitamin D (nmol/l)
Outcome Description:
Vitamin D measured in a blood sample to define the dose-response relationship between UVB dose, UV intensity and Vitamin D production in the skin after UVB exposure.
Outcome Time Frame:
2 days after exposure
Safety Issue:
Yes
Principal Investigator
Hans Christian Wulf, Professor
Investigator Role:
Study Chair
Investigator Affiliation:
Bispebjerg Hospital, Deparment of Dermatology
Authority:
Denmark: The Danish National Committee on Biomedical Research Ethics
Study ID:
271-08-0461
NCT ID:
NCT01074541
Start Date:
January 2008
Completion Date:
February 2010
Related Keywords:
- Vitamin D Status
- Vitamin D
- UVB
- Dose-Response
- UV intensity
- Skin cancer
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