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ERCC1 Expression as a Predictor of Progression Free and Overall Survival in Patients With Epithelial Ovarian Cancer Treated on GOG Protocols 0172 and 0182


N/A
18 Years
N/A
Not Enrolling
Female
Fallopian Tube Cancer, Ovarian Cancer, Peritoneal Cavity Cancer

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Trial Information

ERCC1 Expression as a Predictor of Progression Free and Overall Survival in Patients With Epithelial Ovarian Cancer Treated on GOG Protocols 0172 and 0182


OBJECTIVES:

Primary

- To evaluate ERCC1 tumor expression, as measured by IHC, as a predictor of
progression-free and overall survival of patients with advanced ovarian epithelial
cancer.

Secondary

- To correlate ERCC1 single-nucleotide polymorphisms (C8092A and codon 118) with ERCC1
tumor expression.

OUTLINE: This is a multicenter study.

Blood and paraffin-embedded tumor tissue samples are analyzed for ERCC1 tumor expression by
IHC and single-nucleotide polymorphisms.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Histologically confirmed advanced invasive ovarian epithelial carcinoma, fallopian
tube adenocarcinoma, or primary peritoneal carcinoma

- Has undergone optimal surgical staging

- Has received chemotherapy on either GOG-0172 or GOG-0182

- Adequate blood or DNA available for ERCC1 analysis

- Adequate tumor on paraffin-embedded tissue for IHC staining

PATIENT CHARACTERISTICS:

- Not specified

PRIOR CONCURRENT THERAPY:

- See Disease Characteristics

Type of Study:

Observational

Study Design:

N/A

Outcome Measure:

Association between ERCC1 tumor expression and progression-free and overall survival

Safety Issue:

No

Principal Investigator

Thomas C. Krivak, MD

Investigator Role:

Study Chair

Investigator Affiliation:

University of Pittsburgh

Authority:

Unspecified

Study ID:

CDR0000663840

NCT ID:

NCT01074398

Start Date:

February 2010

Completion Date:

Related Keywords:

  • Fallopian Tube Cancer
  • Ovarian Cancer
  • Peritoneal Cavity Cancer
  • recurrent ovarian epithelial cancer
  • stage III ovarian epithelial cancer
  • stage IV ovarian epithelial cancer
  • fallopian tube cancer
  • peritoneal cavity cancer
  • Ovarian Neoplasms
  • Peritoneal Neoplasms
  • Fallopian Tube Neoplasms
  • Neoplasms, Glandular and Epithelial

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