ERCC1 Expression as a Predictor of Progression Free and Overall Survival in Patients With Epithelial Ovarian Cancer Treated on GOG Protocols 0172 and 0182
OBJECTIVES:
Primary
- To evaluate ERCC1 tumor expression, as measured by IHC, as a predictor of
progression-free and overall survival of patients with advanced ovarian epithelial
cancer.
Secondary
- To correlate ERCC1 single-nucleotide polymorphisms (C8092A and codon 118) with ERCC1
tumor expression.
OUTLINE: This is a multicenter study.
Blood and paraffin-embedded tumor tissue samples are analyzed for ERCC1 tumor expression by
IHC and single-nucleotide polymorphisms.
Observational
N/A
Association between ERCC1 tumor expression and progression-free and overall survival
No
Thomas C. Krivak, MD
Study Chair
University of Pittsburgh
Unspecified
CDR0000663840
NCT01074398
February 2010
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