Proton Beam Radiotherapy for Medulloblastoma and Pineoblastoma: An Assessment of Acute Toxicity and Long Term Neurocognitive, Neuroendocrine and Ototoxicity Outcomes
- Before beginning radiation therapy, participants will have scans done in order to
prepare for the radiation treatment. Doctors will use information gathered from these
scans to plan the best way to deliver radiation to the tumor.
- The following procedures will be performed either before or during the radiotherapy:
Hearing exam; neurocognitive exam; blood tests and cerebral spinal fluid test.
- Not everyone who participates in this study will receive the same amount of proton
radiation therapy. The length of time and amount of radiation received will depend
upon the condition of the participant's disease. Radiation treatment will be given
once a day, 5 days a week (Monday-Friday). The overall treatment course will be
approximately 6 weeks.
Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Incidence and severity of ototoxicity at three years following the completion of radiation therapy.
Torunn I Yock, MD
Massachusetts General Hospital
United States: Institutional Review Board
|MD Anderson Cancer Center||Houston, Texas 77030-4096|
|Massachusetts General Hospital||Boston, Massachusetts 02114-2617|