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Natural Killer Cell KIR and HLA Genotypes May Predict Response to Antibody Therapy in Follicular Lymphoma


N/A
18 Years
N/A
Open (Enrolling)
Both
Lymphoma

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Trial Information

Natural Killer Cell KIR and HLA Genotypes May Predict Response to Antibody Therapy in Follicular Lymphoma


OBJECTIVES:

Primary

- To test the hypothesis that killer immunoglobulin-like receptor (KIR) and HLA genotypes
predict 12-month overall response (complete response, partial response, and unconfirmed
complete response) in patients with follicular lymphoma treated with
rituximab-containing monoclonal antibody combinations on CALGB-50402 or CALGB-50701.

Secondary

- To test the hypothesis that KIR and HLA genotypes are associated with survival outcomes
(progression-free and overall survival) in these patients.

OUTLINE: This is a multicenter study.

Genomic DNA is extracted from previously collected whole blood samples for killer
immunoglobulin-like receptor (KIR) and HLA genotyping and polymorphism analysis.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Diagnosis of follicular lymphoma

- Has received rituximab-containing monoclonal antibody therapy on CALGB-50402 or
CALGB-50701

PATIENT CHARACTERISTICS:

- Not specified

PRIOR CONCURRENT THERAPY:

- See Disease Characteristics

Type of Study:

Observational

Study Design:

N/A

Outcome Measure:

Association between killer immunoglobulin-like receptor (KIR) and HLA genotypes and 12-month overall response

Safety Issue:

No

Principal Investigator

Jeffrey M. Venstrom, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Memorial Sloan-Kettering Cancer Center

Authority:

United States: Federal Government

Study ID:

CDR0000664103

NCT ID:

NCT01057459

Start Date:

February 2010

Completion Date:

Related Keywords:

  • Lymphoma
  • contiguous stage II grade 1 follicular lymphoma
  • contiguous stage II grade 2 follicular lymphoma
  • contiguous stage II grade 3 follicular lymphoma
  • noncontiguous stage II grade 1 follicular lymphoma
  • noncontiguous stage II grade 2 follicular lymphoma
  • noncontiguous stage II grade 3 follicular lymphoma
  • stage III grade 1 follicular lymphoma
  • stage III grade 2 follicular lymphoma
  • stage III grade 3 follicular lymphoma
  • stage IV grade 1 follicular lymphoma
  • stage IV grade 2 follicular lymphoma
  • stage IV grade 3 follicular lymphoma
  • Lymphoma
  • Lymphoma, Follicular

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