Usefulness of the Determination of Body Composition for Establishing New Cut-offs for the Diagnosis and Follow-up of Obesity and Comorbidities
The prevalence of overweight and obesity has increased alarmingly in the last decades.
Obesity is a serious medical problem because it increases the risk of hypertension, type 2
diabetes mellitus, coronary heart disease, sleep-breathing disorders, and certain forms of
cancer. Obesity is defined medically as a state of increased adipose tissue of sufficient
magnitude to produce adverse health consequences. The definition of obesity is based on an
excess of body fat, not of BMI. However, BMI is the reference used to establish a graded
classification of weight relative to height. Although BMI is widely used as a simple
surrogate measure of body fat and has been shown to correlate closely with adiposity, it
would be more appropriate to determine body fat percentage and to use this value for
classification purposes. The present study contemplates the determination of the per cent
body fat (by air displacement plethysmography) in more than 5,000 subjects representing the
whole BMI range, with the aim of establishing new diagnostic and therapeutic criteria
according to the associated comorbidities. The specific objectives are: a) To know the body
fat percentage means for normal weight, overweight and obesity for both sexes. b) To know
the body fat percentage means for normal weight, overweight and obesity for the different
age ranges. c) To analyse the relationship between body fat percentage and BMI values in
order to detect misclassified individuals. d) To establish new cut-offs for body fat
percentage and the normality ranges according to its relationship with cardiovascular risk
factors that could be useful in the diagnosis and therapy of obesity.
Observational
Observational Model: Cohort, Time Perspective: Cross-Sectional
Gema Frühbeck, MD, PhD
Principal Investigator
Clínica Universidad de Navarra
Spain: Ethics Committee
OBECUN-BF-01
NCT01055626
January 2005
December 2013
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