Trial Information

Early Start of Oral Sildenafil 100mg for Erectile Dysfunction After Robotic Assisted Laparoscopic Radical Prostatectomy

Various studies using animal models of CN neuroparaxia and clinical trials have demonstrated
somewhat beneficial effect of PDE-5 inhibitors on smooth muscle cells of the corpus
cavernosum. PDE-5 inhibitors including sildenafil have demonstrated the effectiveness in the
management of postprostatectomy ED. In the animal experiments, PDE-5 inhibitors lowered the
severity of the fibrosis in the corpus cavernosum of rats with CN cutting. In the clinical
trials, on-demand dosing or routine dosing of PDE-5 inhibitors improved the potency rates in
men received NSRP, and improvements of the potency rate did not appear to be statistically
different among two dosing regimens.

But, there are few studies on the potency rate according to the start time of the
administration of PDE-5 inhibitors (eg. early vs. delayed post-operative dosing). At
present, it is not conclusive that whether nerve-sparing RALP provides more higher potency
rate than conventional surgery in men with prostate cancers. But, with more precise
dissection of CN, the robotic surgery appears to have more chances to maintain the potency
in men received RP.