Inclusion Criteria

- INCLUSION CRITERIA:

Women who are clinically indicated for screening mammography according to the National
Comprehensive Cancer Network (NCCN) guidelines (3) and the American Cancer Society
guidelines:

1. All women who fall under the ACS mammography guidelines

2. Women younger than 40 years but with more than 20% lifetime risk for developing
breast cancer:

1. Prior personal history of prior thoracic radiation therapy between the age of 10
and 30, such as for Hodgkin's disease. In this case, women are eligible
beginning 8-10 years after radiotherapy or at age 40, whichever comes first.

2. 5-year risk of invasive breast cancer (greater than or equal to 1.7% of women
greater than or equal to 35 years or women who have a life time risk greater
than 20% as defined by models that are largely dependent on family history.

3. Strong family history;

i. First degree relative diagnosed with breast, ovarian, fallopian tube, or primary
peritoneal cancer.

ii. Individual from families known to have BRCA 1 or 2 gene mutation.

iii. Close male blood relative with breast cancer.

d. Genetic predisposition;

i. Carry or have first-degree relative who carries a genetic mutation in the BRCA 1
or 2 genes.

ii. Carry or have a first-degree relative who carries a genetic mutation in the TP53
or PTEN genes (Li-Fraumeni syndrome and Cowden Bannayan-Riley-Ruvalcaba syndromes).

e. A personal history of Lobular carcinoma in situ (LCIS) and/or atypical ductal
hyperplasia (ADH)

f. Prior personal history of breast cancer or ovarian cancer.

i. Starting at the age of 25 year for Hereditary breast and ovarian cancer patients.

ii. 5-10 years prior to youngest breast cancer case for strong family history or
other genetic predisposition.

g. Woman and Minorities

EXCLUSION CRITERIA:

Pregnant or lactating subjects.