Inclusion Criteria:

- Adequate renal function defined as: serum creatinine 2.0 x normal, or creatinine
clearance or radioisotope GFR > 40 ml/min/m2 or > 40 ml/min/1.73 m2 or an equivalent
GFR as determined by the institutional normal range.

- Adequate liver function defined as: total bilirubin < 2.5 x normal; or SGOT (AST) or
SGPT (ALT) < 5.0 x normal.

- Adequate cardiac function defined as: shortening fraction of > 25% by echocardiogram,
or ejection fraction of > 40% by radionuclide angiogram or echocardiogram.

- Adequate pulmonary function defined as: DLCO > 35% by pulmonary function test. For
children who are uncooperative, no evidence of dyspnea at rest, no exercise
intolerance, and a pulse oximetry > 94% in room air.

- Diseases:

- CML (CP, AP or BC)

- AML/MDS/JCML

- ALL

- Lymphoma (Hodgkin's and non-Hodgkin's)

- Non-malignant disorders

- Bone Marrow Failure Syndromes: Patients with the following diagnoses are eligible:

- Severe Aplastic Anemia:

- Fanconi Anemia

- Severe Congenital Neutropenia (Kostmann's Syndrome)

- Amegakaryocytic Thrombocytopenia

- Diamond-Blackfan Anemia

- Infantile Osteopetrosis

- Schwachman-Diamond Syndrome

- Dyskeratosis Congenita

- Other bone marrow failure syndromes at discretion of Principal Investigator

- Immunodeficiencies:

- SCIDS, all subtypes

- Combined Immunodeficiency Syndrome

- Wiskott-Aldrich syndrome

- Chronic Granulomatous Disease

- Chediak-Higashi Syndrome

- Leukocyte Adhesion Deficiency

- Other immunodeficiencies at discretion of Principal Investigator

- Inborn Errors of Metabolism (IEOM):

- Transplant is recommended for the following disorders: Hurler syndrome
(L-iduronidase deficiency, MPS-I), Maroteaux-Lamy syndrome
(galactosamine-4-sulfatase deficiency, MP VI), Sly syndrome (glucuronidase
deficiency, MPS-VII), Globoid cell Leukodystrophy
(galactocerebrosidasedeficiency), Metachromatic leukodystrophy (arylsulfatase A
deficiency), Childhood-onset X-linked adrenoleukodystrophy (X-ALD), Fucosidosis
(fucosidase deficiency), Mannosidosis, Aspartylglucosaminuria, Niemann-Pick
Disease Type B (acid sphingomyelinase deficiency), Gaucher disease
(glucocerebrosidase deficiency) Type I (non neuropathic), Other diagnoses may be
considered at the discretion of the Principal Investigator

- For X-ALD patients greater than 5 years of age, IQ > 80 is required. For other
patients greater than 5 years of age, IQ > 70 is required.

- For patients less than 5 years of age, the developmental quotient or clinical
neurodevelopmental examination should demonstrate potential for stabilization at
a level of functioning where continuous life support (e.g. mechanical
ventilation) would not be predicted to be required in the year following
transplantation.

- Histiocytosis:

- Hemophagocytic Lymphohistiocytosis (HLH)

- Familial Erythrophagocytic Lymphohistiocytosis

- Langerhans Cell Histiocytosis

- Malignant Histiocytosis

- Other Malignant and non-malignant diseases: Other malignant and non-malignant
diseases not listed above may be eligible if deemed appropriate by the Principal
Investigator.

Exclusion Criteria:

- Women who are pregnant and/or breast feeding are ineligible