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Motor Proficiency And Physical Activity in Adult Survivors of Childhood ALL


N/A
18 Years
N/A
Open (Enrolling)
Both
Acute Lymphoblastic Leukemia

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Trial Information

Motor Proficiency And Physical Activity in Adult Survivors of Childhood ALL


The study will focus on the following primary objectives:

1. Enumerate the prevalence of musculoskeletal, sensory, and fitness impairments among
adult survivors of childhood ALL. The study hypothesizes that adult survivors of
childhood ALL will have a higher prevalence of musculoskeletal, sensory and fitness
impairments than a control group frequency matched on race/ethnicity, age, and gender.

2. Evaluate the association between personal and treatment factors and musculoskeletal,
sensory and fitness impairments. The study hypothesizes that:

- Female gender, younger age at diagnosis, and cranial radiation will be associated
with decreased lean body mass.

- Female gender, younger age at diagnosis, and type of glucocorticoid (dexamethasone
vs. prednisone) treatment will be associated with muscle weakness.

- Sensory loss will vary as a function of age, with participants diagnosed at 12+
years of age demonstrating vincristine related sensory loss, and those diagnosed
at <12 years of age demonstrating dexamethasone and/or intrathecal methotrexate
related sensory loss.

- Fitness impairments will be evident in participants who received 100 mg/m2+ of
anthracyclines.

The study will focus on the secondary objectives:

1. Compare physical activity patterns between adult survivors of childhood ALL and a
frequency matched control group. The study hypothesizes that adult survivors of
childhood ALL will demonstrate lower levels of physical activity as measured with an
activity monitor (accelerometer), and will report lower levels of overall physical
activity, when compared to members of the comparison group.

2. Describe the association between habitual physical activity and energy expenditure
among ALL survivors. The study hypothesizes that activity levels, measured with the
accelerometer, will be positively correlated with energy expenditure, measured using
the doubly labeled water technique.

3. Explore the associations between musculoskeletal and sensory health, and physical
activity patterns among adult survivors of childhood ALL. The study hypothesizes that
adult survivors of childhood ALL with lower proportions of lean muscle mass and/or
sensory loss indicating peripheral neuropathy will demonstrate the lowest levels of
physical activity.


Inclusion Criteria:

(ALL survivors):

1. Research participant who is a survivor of childhood ALL who was treated at St. Jude
Children's Research Hospital between 1980 and 1999

2. Research participant must be at least ten years from diagnosis

3. Research participant must be at least 18 years of age at the time of the scheduled
evaluation

Exclusion Criteria (ALL survivors):

1. Research participant who has Down Syndrome or congenital cognitive, musculoskeletal
or cardiopulmonary impairments that interfere with motor function

2. Research participant currently pregnant or lactating

3. Research participant age 17 years or less

4. Research participant undergoing active treatment for cancer

Inclusion Criteria (Comparison Group)

1. Research participant is a sibling, parent, relative or friend of a current or former
St. Jude patient.

2. Research participant must be at least 18 years of age at the time of the scheduled
evaluation

Exclusion Criteria (Comparison Group)

1. Research participant who has Down Syndrome or congenital cognitive, musculoskeletal
or cardiopulmonary impairments that interfere with motor function

2. Research participant currently pregnant or lactating

3. Research participant age 17 years or less

4. Research participant has a medical history of cancer

5. Research participant is a first degree relative of a survivor participating in MTRPAL

Type of Study:

Observational

Study Design:

Observational Model: Case Control, Time Perspective: Cross-Sectional

Outcome Measure:

Ascertain the prevalence of musculoskeletal, sensory, and fitness impairments among adult survivors of childhood ALL.

Outcome Time Frame:

Day 1-2

Safety Issue:

No

Principal Investigator

Kirsten K Ness, PT, Ph.D

Investigator Role:

Principal Investigator

Investigator Affiliation:

St. Jude Children's Research Hospital

Authority:

United States: Institutional Review Board

Study ID:

MTRPAL

NCT ID:

NCT01047020

Start Date:

June 2009

Completion Date:

April 2013

Related Keywords:

  • Acute Lymphoblastic Leukemia
  • Impairments of musculoskeletal Health;
  • Physical activity;
  • Motor Proficiency;
  • Leukemia
  • Leukemia, Lymphoid
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma

Name

Location

St. Jude Children's Research HospitalMemphis, Tennessee  38105-2794