Inclusion Criteria:

Hepatic Patients:

- Female patient is of non-child bearing potential

- Apart from hepatic insufficiency with features of cirrhosis, patient is otherwise in
good health

- Patient has a diagnosis of chronic stable hepatic insufficiency with features of
cirrhosis

Healthy Subjects:

- Female subject is of non-childbearing potential

- Subject is in good health

Exclusion Criteria:

Hepatic Patients and Healthy Subjects:

- Patient works a night shift and is not able to avoid night shift work during the
study

- Patient has a history of stroke, seizure or major neurological disease

- Patient has a history of cancer

- Patient is unable to refrain from or anticipates the use of any prescription or
non-prescription drugs during the study

- Patient consumes excessive amounts of alcohol or caffeine

- Patient has had major surgery, donated blood or participated in another
investigational study in the past 4 weeks