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Multicenter Cross Sectional Study of Primary Intestine Lymphoma: Treatment Outcome and Quality of Life

15 Years
85 Years
Not Enrolling
Non-Hodgkin Lymphoma of Intestine

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Trial Information

Multicenter Cross Sectional Study of Primary Intestine Lymphoma: Treatment Outcome and Quality of Life

Intestine is the one of commonly involved extranodal sites of non-Hodgkin's lymphoma (NHL).
Thus, small and large Intestine account for approximately 30-40% of primary gastrointestinal
tract lymphoma. More than 70% of intestinal lymphoma presents as localized disease, and
surgery such as bowel resection is performed in many patients with intestinal lymphoma for
diagnosis and treatment. However, it is still unclear whether surgical resection followed by
chemotherapy is superior to systemic chemotherapy alone in terms of treatment outcome and
quality of life (QOL). Thus, we analyze the clinical features and treatment outcome of
patients with NHL of intestine, and at the same time perform a multicenter cross-sectional
study about the QOL in survivors of intestine NHL. We evaluates the treatment outcomes of
patients with intestine NHL from hospitals affiliated with the Consortium for Improving
Survival of Lymphoma (CISL) in Korea. We assess the QOL of survivors who completed their
treatment using the EORTC QLQ-C30 questionnaire.

Inclusion Criteria:

- Primary intestine lymphoma.

Definition of primary intestine lymphoma:

1. Dominant site should be small and large intestine with or without regional lymph node

2. Distant lymph node involvement can be allowed if the intestine lesion is the
presenting site

3. Contiguous involvement of other organs such as liver, spleen can be allowed

Exclusion Criteria:

- Intestine involvement as a dissemination process in stage IV nodal lymphoma

Type of Study:


Study Design:

Observational Model: Case Control, Time Perspective: Cross-Sectional

Outcome Measure:

Overall survival

Outcome Time Frame:

Study entry

Safety Issue:


Principal Investigator

Seok Jin Kim, MD.,PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Samsung Medical Center


Korea: Institutional Review Board

Study ID:




Start Date:

September 2008

Completion Date:

March 2010

Related Keywords:

  • Non-Hodgkin Lymphoma of Intestine
  • lymphoma, intestine, outcome, quality of life
  • Lymphoma
  • Lymphoma, Non-Hodgkin