Inclusion Criteria:

1. Aged 18 to 70 years old (patient over 60 years old must not have three kinds of
complications of heart, lung, liver and kidney function at the same time), no gender
limited;

2. Advanced malignant solid tumors confirmed by histology or cytology ( skin cancer and
esophageal cancer), malignant tumor can be illuminated directly (or via endoscopy)
by the laser fiber;

3. Recurrence after surgery, radiotherapy,chemoradiotherapy; or have financial
difficulties, give up any other treatment;

4. Patients received chemotherapy, biological therapy or other research drugs must
exceed at least 4 weeks or more than five half-life;

5. Life expectancy: > 3 months;

6. Can collaboratively observe the adverse events and efficacy;

7. No other anti-tumor treatment (including steroids);

8. Patients or their legal representative can sign the informed consent;

9. Performance status: ECOG ≤ 2,

Exclusion Criteria:

1. No pathological evidence;

2. Have allergic effect to this drug;

3. HIV antibody positive, or suffering from other acquired and congenital immune
deficiency diseases, or have organ transplant history;

4. Neutrophil count < 1.5 × 109 / L, platelet < 100 × 109 / L, or hemoglobin < 90 g /L;

5. Serum Cr above 1.5 times of normal reference range or Cr clearance rate < 50 ml/min;

6. ALT, or AST > 2.5 times of the normal range when no hepatic metastasis occur; or ALT,
or AST > 5 times of the normal range when hepatic metastasis exist;

7. Serum bilirubin > 1.5 times of the normal range;

8. Fever above 38 ℃, or have active infection which can affect the clinical trials
obviously;

9. Hypertension failed to be controlled (systolic blood pressure > 160 mmHg or diastolic
pressure > 100 mmHg);

10. Obvious cardiovascular disorders (eg, myocardial infarction, superior vena cava
syndrome, more than two grades heart disease, or heart disease which can increase the
risk of ventricular arrhythm);

11. Not recover from any anticancer therapy or surgery;

12. Any clinical problems beyond control (such as severe mental, neurological,
cardiovascular, respiratory system diseases, etc.);

13. Evidence of central nerve system metastasis;

14. Have some gastrointestinal disease which can affect the distribution, metabolism or
removal of this drug;

15. Pregnant or breast-feeding women;

16. Poor compliance.