Inclusion Criteria:

Inclusion Criteria - OHT:

- Ocular hypertension defined as an IOP ≥ 24 mm Hg and ≤ 32 mm Hg in one eye and IOP ≥
22 mm Hg and ≤ 32 mm Hg in the fellow eye

- Normal optic disc

- Normal visual field defined as follows:

- Mean Deviation (MD) or Pattern Standard Deviation (PSD) of p>5%

- Normal Glaucoma Hemifield Test (GHT)

- Reliable visual field exam (less than 33% false positives or false negatives, and
less than 20% fixation losses)

Inclusion Criteria - POAG:

- Glaucomatous visual field loss defined as a CPSD (p < 0.05), or GHT (p < 1%) outside
normal limits with consistent with ONH or NFL defect

- Early visual field loss defined as MD ≤ -6.0 dB

- Untreated IOP ≤ 32 mmHg

- ONH or NFL defect defined as either inter-eye CDR asymmetry > 0.2, rim thinning or
notching, or NFL bundle defect visible on slitlamp biomicroscopy and stereo color
fundus photography

Exclusion Criteria:

Exclusion Criteria - OHT:

- Best-corrected visual acuity less than 20/40 either eye

- Abnormal or unreliable VF

- Untreated IOP > 32 mmHg

- Age < 18 or >85 years

- Refractive error of > +3.00 D or < -7.00 D

- Previous intraocular surgery except for uncomplicated cataract extraction with
posterior chamber intraocular lens implantation

- Need for chronic ocular or systemic corticosteroid use

- Narrow/closed angle (gonioscopy must show 75% or more of the angle to be Grade 2 or
more by Shaffer's grading system)

- Diabetic retinopathy

- Other diseases that may cause VF loss or optic disc abnormalities

- Life-threatening or debilitating illness making it unlikely patient could
successfully complete the study

- Inability to clinically view or photograph the optic discs due to media opacity or
poorly dilating pupil

- Refusal of informed consent or of commitment to the full length of the study

- Contraindication to latanoprost or placebo vehicle

Exclusion criteria - POAG:

- Best-corrected visual acuity less than 20/40

- Untreated IOP > 32 mmHg

- Age < 18 or >85 years

- Refractive error of > +3.00 D or < -7.00 D

- Previous intraocular surgery except for uncomplicated cataract extraction with
posterior chamber intraocular lens implantation

- Diabetic retinopathy

- Other diseases that may cause VF loss or optic disc abnormalities

- Inability to clinically view or photograph the optic discs due to media opacity or
poorly dilating pupil

- Inability to perform reliably on automated VF testing

- Life-threatening or debilitating illness making it unlikely patient could
successfully complete the study.

- Refusal of informed consent or of commitment to the full length of the study

- Contraindication to latanoprost or placebo vehicle