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Molecular Epidemiology of Esophageal Cancer: Pilot Project


N/A
18 Years
N/A
Open (Enrolling)
Both
Esophageal Cancer

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Trial Information

Molecular Epidemiology of Esophageal Cancer: Pilot Project


OBJECTIVES:

- Examine the role of several genetically-determined factors in combination with
cigarette smoking and diet in the etiology and prevention of esophageal cancer.

- Identify polymorphisms in metabolizing enzymes (e.g., phase I or II metabolism [GSTM1,
GSTT1,CYP1A1, CYP3A5, mEH, NQO1, GSTP1], DNA repair [XRCC1, ERCC2], free-radical
formation [MPO, MnSOD], inflammatory genes [ IL1-beta], metastatic potential [MMP1],
and cell cycle or tumor suppression [p21, p53]) and related path genes of
susceptibility for esophageal cancer.

OUTLINE: Blood and tumor tissue samples are collected. DNA purified from these samples is
analyzed using DNA-based assays to determine polymorphisms in various related gene pathways.

Patients complete questionnaires concerning environmental, smoking and diet habits.

PROJECTED ACCRUAL: A total of 1,000 tissue samples from patients and healthy participants
(750 patients and 250 healthy participants) will be accrued for this study.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Meets 1 of the following criteria:

- Diagnosis of esophageal cancer (patient)

- Newly diagnosed disease

- Receiving care at Massachusetts General Hospital, Thoracic Oncology Center

- Friend or spouse of patient (healthy participants)

PATIENT CHARACTERISTICS:

- No concurrent psychiatric incapacity or dementia

PRIOR CONCURRENT THERAPY:

- Not specified

Type of Study:

Observational

Study Design:

N/A

Outcome Measure:

Polymorphisms in various pathways, DNA repair, free-radical formation, inflammatory genes, metastatic potential, and cell cycle or tumor suppression in blood samples

Safety Issue:

No

Principal Investigator

David C. Christiani, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Massachusetts General Hospital

Authority:

Unspecified

Study ID:

CDR0000450143

NCT ID:

NCT01035398

Start Date:

Completion Date:

Related Keywords:

  • Esophageal Cancer
  • stage 0 esophageal cancer
  • stage I esophageal cancer
  • stage II esophageal cancer
  • stage III esophageal cancer
  • stage IV esophageal cancer
  • Esophageal Diseases
  • Esophageal Neoplasms

Name

Location
Massachusetts General Hospital Boston, Massachusetts  02114-2617
Harvard School of Public Health Boston, Massachusetts  02115