Inclusion Criteria:

1. Resectable liver metastasis from colorectal cancer(the distance from the tumor lower
edge to anal more than 12cm),no visible extrahepatic metastatic tumors. Curable by
resection, as determined by a surgeon and imaging physicians. The minimum of the
liver metastases needs ≥2cm. Patients can be recruited if meet the conditions about:

- Primary tumor had been removed of the metachronous liver metastasis patients and
no residue from the eyes or microscope.

- Primary tumor has been removed more than 1 month of the simultaneous liver
metastasis patients.

2. Age of≥18 and ≤80

3. ECOG≤2

4. Signed written informed consent

Exclusion Criteria:

1. Peripheral neuropathy(CTC＞1)

2. Had a neurological or mental disorders

3. Active infection

4. Allergy to Platinum-based and other drugs

5. Other acute diseases including infection, heart-disease(CHF, stable or unstable
angina)

6. Pregnant or nursing patients