A Prospective Study Implementing MRI Based Treatment Planning for Clinical Target Volume Definition and Immobilization in Post-Prostatectomy Radiation Treatment
I. To evaluate the use of MRI in delineating clinical target volumes, as well as endorectal
balloon target immobilization in patients treated with radiation following radical
II. Trends over time in CTV, bladder and rectum volumes and percent change from baseline at
each time point. III. Frequency of events in which the CTV falls outside the PTV. IV.
Proportion of the total CTV which falls outside the PTV at each event. V. Trends over time
in dose-volume exposures for bladder and rectum.
OUTLINE: Patients undergo MRI and CT scan-based simulation for treatment planning with
endorectal balloon target immobilization. The treatment target volumes and surrounding
organs at risk are contoured, treatment plan developed and approved.
Patients then undergo 39 fractions of image-guided intensity-modulated radiotherapy over 8
weeks. Patients also undergo weekly MRI scans of the pelvis (in the planned treatment
position) during radiotherapy.
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Clinical treatment target motion and deformation as quantified by co-registration of weekly MRI scans with original treatment planning MRI scans
Abramson Cancer Center of the University of Pennsylvania
United States: Institutional Review Board
|Abramson Cancer Center of the University of Pennsylvania||Philadelphia, Pennsylvania 19104-4283|