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Genetic Predictors of AML Treatment Response


N/A
N/A
30 Years
Open (Enrolling)
Both
Leukemia

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Trial Information

Genetic Predictors of AML Treatment Response


OBJECTIVES:

- Perform a genome-wide scan to test for loci associated with acute myeloid leukemia
(AML) relapse and infection risk.

- Validate positive associations seen in the genome-wide scan with a fine mapping
approach.

- Perform simulated clinical trials using germline genetic variation data to test the
feasibility of using genetic data to inform the clinical care of pediatric patients
with AML.

OUTLINE: This is a multicenter study.

Germline DNA is obtained from previously collected peripheral blood or bone marrow samples
for array-based genotyping studies, including genome-wide association studies (single
nucleotide polymorphisms) and fine mapping genotyping.

Clinical trial simulations are performed to test the clinical applicability of using genetic
variation data in the management of infectious complications.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Diagnosis of acute myeloid leukemia (AML)

- In remission

- Adequate DNA from peripheral blood or bone marrow samples

- Concurrent enrollment on CCG-2961, COG-AAML03P1, COG-AAML0531, AML-93, AML-97,
AML-04, AML-09, or Canada AML Infection clinical trial required

PATIENT CHARACTERISTICS:

- Not specified

PRIOR CONCURRENT THERAPY:

- See Disease Characteristics

Type of Study:

Observational

Study Design:

N/A

Outcome Measure:

First acute myeloid leukemia relapse

Safety Issue:

No

Principal Investigator

Richard Aplenc, MD, MSCE

Investigator Role:

Study Chair

Investigator Affiliation:

Children's Hospital of Philadelphia

Authority:

United States: Federal Government

Study ID:

CDR0000660540

NCT ID:

NCT01024127

Start Date:

December 2009

Completion Date:

Related Keywords:

  • Leukemia
  • adult acute myeloid leukemia in remission
  • childhood acute myeloid leukemia in remission
  • adult acute myeloid leukemia with 11q23 (MLL) abnormalities
  • adult acute myeloid leukemia with del(5q)
  • adult acute myeloid leukemia with inv(16)(p13;q22)
  • adult acute myeloid leukemia with t(15;17)(q22;q12)
  • adult acute myeloid leukemia with t(16;16)(p13;q22)
  • adult acute myeloid leukemia with t(8;21)(q22;q22)
  • Leukemia
  • Leukemia, Myeloid, Acute
  • Leukemia, Myeloid

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